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Solute Carrier Family 35, Member A3 (SLC35A3)

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UDP-N-acetylglucosamine transporter; Golgi UDP-GlcNAc transporter

Solute Carrier Family 35, Member A3 (SLC35A3)
CCC P676
HGNC 11023
MGI 1917648
PubMed 24031089
RGD 1308615
UniProt Q9Y2D2
The deduced 325-amino acid protein is 54% identical to SLC35A2. Northern blot analysis revealed ubiquitous expression of 2.4- and 6.2-kb transcripts. Immunoblot analysis showed that SLC35A3 is expressed as an approximately 30-kD protein. Immunofluorescence microscopy demonstrated association with the Golgi apparatus. Substrate analysis established that SLC35A3 is a highly active transporter of UDP-N-acetylglucosamine.
CVM is caused by mutation in the Golgi-resident nucleotide-sugar transporter encoded by SLC35A3. The disease showed complete cosegregation with the mutation in a homozygous state, and proteome patterns indicated abnormal protein glycosylation in tissues of affected animals.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Solute Carrier Family 35, Member A3 (SLC35A3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Solute Carrier Family 35, Member A3 (SLC35A3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Solute Carrier Family 35, Member A3 (SLC35A3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Solute Carrier Family 35, Member A3 (SLC35A3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Solute Carrier Family 35, Member A3 (SLC35A3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Solute Carrier Family 35, Member A3 (SLC35A3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Solute Carrier Family 35, Member A3 (SLC35A3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Solute Carrier Family 35, Member A3 (SLC35A3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Solute Carrier Family 35, Member A3 (SLC35A3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Solute Carrier Family 35, Member A3 (SLC35A3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Solute Carrier Family 35, Member A3 (SLC35A3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Solute Carrier Family 35, Member A3 (SLC35A3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Solute Carrier Family 35, Member A3 (SLC35A3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Solute Carrier Family 35, Member A3 (SLC35A3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Solute Carrier Family 35, Member A3 (SLC35A3) ELISA Kit Customized Service Offer
  1. "Molecular cloning and functional expression of the human Golgi UDP-N-acetylglucosamine transporter."J. Biochem. 126:68-77(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "UDP-N-acetylglucosamine transporter and UDP-galactose transporter form heterologous complexes in the Golgi membrane."FEBS Lett. 586:4082-4087(2012) [PubMed] [Europe PMC] [Abstract]
  7. "Mutations in SLC35A3 cause autism spectrum disorder, epilepsy and arthrogryposis."J. Med. Genet. 50:733-739(2013) [PubMed] [Europe PMC] [Abstract]