≡

Sortilin Related Receptor, L A Repeats Containing (SORL1)

[Edit]

Gp250; LR11; LRP9; SorLA-1; C11orf32; Low-density lipoprotein receptor relative with 11 ligand-binding repeats; Sorting protein-related receptor containing LDLR class A repeats

Sortilin Related Receptor, L A Repeats Containing (SORL1)
CCC P669
HGNC 11185
MGI 1202296
PubMed 18090307
RGD 619914
UniProt Q92673
Wiki SORL1
SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 (VPS10) domain-containing receptor family, and the low density lipoprotein receptor (LDLR) family. The encoded protein also contains fibronectin type III repeats and an epidermal growth factor repeat. The encoded protein is translated as a preproprotein and likely plays roles in endocytosis and sorting. There may be an association between expression of this locus and Alzheimer's Disease.SORL1-transfected COS-7 cells, which have very low levels of furin-like proteases, expressed predominantly unprocessed SORL1. Cotransfection with a furin-encoding vector led to increased release of SORL1 from COS-7 cells into the medium, confirming that furin cleaves the SORL1 propeptide.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sortilin Related Receptor, L A Repeats Containing (SORL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sortilin Related Receptor, L A Repeats Containing (SORL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sortilin Related Receptor, L A Repeats Containing (SORL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sortilin Related Receptor, L A Repeats Containing (SORL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sortilin Related Receptor, L A Repeats Containing (SORL1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sortilin Related Receptor, L A Repeats Containing (SORL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sortilin Related Receptor, L A Repeats Containing (SORL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sortilin Related Receptor, L A Repeats Containing (SORL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sortilin Related Receptor, L A Repeats Containing (SORL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sortilin Related Receptor, L A Repeats Containing (SORL1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sortilin Related Receptor, L A Repeats Containing (SORL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sortilin Related Receptor, L A Repeats Containing (SORL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sortilin Related Receptor, L A Repeats Containing (SORL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sortilin Related Receptor, L A Repeats Containing (SORL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sortilin Related Receptor, L A Repeats Containing (SORL1) ELISA Kit Customized Service Offer
  1. "A novel mosaic protein containing LDL receptor elements is highly conserved in humans and chickens."Arterioscler. Thromb. Vasc. Biol. 17:996-1002(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular characterization of a novel human hybrid-type receptor that binds the alpha2-macroglobulin receptor-associated protein."J. Biol. Chem. 271:31379-31383(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "LR11, an LDL receptor gene family member, is a novel regulator of smooth muscle cell migration."Circ. Res. 94:752-758(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein."Proc. Natl. Acad. Sci. U.S.A. 102:13461-13466(2005) [PubMed] [Europe PMC] [Abstract]
  7. "No association of SORL1 SNPs with Alzheimer's disease."Neurosci. Lett. 440:190-192(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Meta-analysis of the association between variants in SORL1 and Alzheimer disease." Arch. Neurol. 68:99-106(2011) [PubMed] [Europe PMC] [Abstract]
  11. "Rho kinase II phosphorylation of the lipoprotein receptor LR11/SORLA alters amyloid-beta production."J. Biol. Chem. 286:6117-6127(2011) [PubMed] [Europe PMC] [Abstract]
  12. "SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians." PLoS ONE 8:E58618-E58618(2013) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  14. "Solution structure of the second FN3 domain of human SORLA/LR11."Submitted (OCT-2006) to the PDB data bank
  15. "GGA autoinhibition revisited."Traffic 11:259-273(2010) [PubMed] [Europe PMC] [Abstract]
  16. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
  17. "SORL1 is genetically associated with increased risk for late-onset Alzheimer disease in the Belgian population."Hum. Mutat. 29:769-770(2008) [PubMed] [Europe PMC] [Abstract]
  18. "High frequency of potentially pathogenic SORL1 mutations in autosomal dominant early-onset Alzheimer disease." Mol. Psychiatry 17:875-879(2012) [PubMed] [Europe PMC] [Abstract]