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Sperm Protein Associated With The Nucleus, X-Linked Family, Member A1 (SPANXA1)

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SPANX; NAP-X; SPAN-Xa; SPAN-Xb; CT11.1; Cancer/Testis Antigen Family 11,Member 1; Nuclear-associated protein SPAN-Xa; SPANX family member A

Sperm Protein Associated With The Nucleus, X-Linked Family, Member A1 (SPANXA1)
CCC P666
HGNC 11218
PubMed 10906052
UniProt Q9NS26
Wiki SPANXA1
SPANXA1 is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene maps to chromosome X in a head-to-head orientation with SPANX family member A1 and appears to be a duplication of that locus.
The protein encoded by this gene targets to the nucleus where it associates with nuclear vacuoles and the redundant nuclear envelope. Based on its association with these poorly characterized regions of the sperm nucleus, this protein provides a biochemical marker to study unique structures in spermatazoa while attempting to further define its role in spermatogenesis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sperm Protein Associated With The Nucleus, X-Linked Family, Member A1 (SPANXA1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sperm Protein Associated With The Nucleus, X-Linked Family, Member A1 (SPANXA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sperm Protein Associated With The Nucleus, X-Linked Family, Member A1 (SPANXA1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sperm Protein Associated With The Nucleus, X-Linked Family, Member A1 (SPANXA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sperm Protein Associated With The Nucleus, X-Linked Family, Member A1 (SPANXA1) ELISA Kit Customized Service Offer
  1. "Spermatid-specific expression of the novel X-linked gene product SPAN-X localized to the nucleus of human spermatozoa."Biol. Reprod. 63:469-481(2000) [PubMed] [Europe PMC] [Abstract]
  2. "The human SPANX multigene family: genomic organization, alignment and expression in male germ cells and tumor cell lines."Gene 309:125-133(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Dynamic structure of the SPANX gene cluster mapped to the prostate cancer susceptibility locus HPCX at Xq27."Genome Res. 15:1477-1486(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]