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Spastic Paraplegia 11 (SPG11)

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Spatacsin; Colorectal carcinoma-associated protein

Spastic Paraplegia 11 (SPG11)
CCC P665
HGNC 11226
MGI 3781826
PubMed 18663179
RGD 1562529
UniProt Q96JI7
Wiki SPG11
Spatacsin is a potential transmembrane protein that is phosphorylated upon DNA damage. Defects in this gene are a cause of spastic paraplegia type 11 (SPG11). Human SPG11 shares 85% identity with the homologous protein in dog, 76% with mouse, and 73% with rat. The spatacsin protein includes 4 putative transmembrane domains, suggesting that the protein may be a receptor or transporter, as well as a leucine zipper and coiled-coil domain. It was assigned to the aromatic compound dioxygenase superfamily because of 22% identity with the consensus sequence between residues 2104 and 2381. The SPG11 gene is expressed ubiquitously in the nervous system but most prominently in the cerebellum, cerebral cortex, hippocampus, and pineal gland.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Spastic Paraplegia 11 (SPG11) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Spastic Paraplegia 11 (SPG11) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Spastic Paraplegia 11 (SPG11) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Spastic Paraplegia 11 (SPG11) CLIA Kit Customized Service Offer
n/a ELISA Kit for Spastic Paraplegia 11 (SPG11) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Spastic Paraplegia 11 (SPG11) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Spastic Paraplegia 11 (SPG11) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Spastic Paraplegia 11 (SPG11) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Spastic Paraplegia 11 (SPG11) CLIA Kit Customized Service Offer
n/a ELISA Kit for Spastic Paraplegia 11 (SPG11) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Spastic Paraplegia 11 (SPG11) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Spastic Paraplegia 11 (SPG11) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Spastic Paraplegia 11 (SPG11) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Spastic Paraplegia 11 (SPG11) CLIA Kit Customized Service Offer
n/a ELISA Kit for Spastic Paraplegia 11 (SPG11) ELISA Kit Customized Service Offer
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  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "A genome-scale DNA repair RNAi screen identifies SPG48 as a novel gene associated with hereditary spastic paraplegia." PLoS Biol. 8:E1000408-E1000408(2010) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  11. "Screening of ARHSP-TCC patients expands the spectrum of SPG11 mutations and includes a large scale gene deletion." Hum. Mutat. 30:E500-E519(2009) [PubMed] [Europe PMC] [Abstract]