Suppression Of Tumorigenicity 14 (ST14)

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SNC19; HAI; MT-SP1; PRSS14; TADG15; Epithin; Matriptase; Prostamin; Membrane-type serine protease 1; Serine protease 14; Tumor-associated differentially-expressed gene 15

Suppression Of Tumorigenicity 14 (ST14)
ST14 is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis. ST14 lacks a signal sequence and is likely to be a membrane-associated serine protease.Expression was also observed in a colorectal adenocarcinoma cell line, but not in several other cell lines tested.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP657Hu01 Recombinant Suppression Of Tumorigenicity 14 (ST14) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAP657Hu01 Polyclonal Antibody to Suppression Of Tumorigenicity 14 (ST14) WB; IHC; ICC; IP.
LAP657Hu71 Biotin-Linked Polyclonal Antibody to Suppression Of Tumorigenicity 14 (ST14) WB; IHC; ICC.
LAP657Hu81 FITC-Linked Polyclonal Antibody to Suppression Of Tumorigenicity 14 (ST14) WB; IHC; ICC; IF.
MAP657Hu21 Monoclonal Antibody to Suppression Of Tumorigenicity 14 (ST14) WB; IHC
LAP657Hu72 Biotin-Linked Monoclonal Antibody to Suppression Of Tumorigenicity 14 (ST14) WB; IHC; ICC.
PAP657Hu02 Polyclonal Antibody to Suppression Of Tumorigenicity 14 (ST14) WB; IHC; ICC; IP.
Assay Kits SEP657Hu ELISA Kit for Suppression Of Tumorigenicity 14 (ST14) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Suppression Of Tumorigenicity 14 (ST14) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Suppression Of Tumorigenicity 14 (ST14) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Suppression Of Tumorigenicity 14 (ST14) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Suppression Of Tumorigenicity 14 (ST14) CLIA Kit Customized Service Offer
n/a ELISA Kit for Suppression Of Tumorigenicity 14 (ST14) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Suppression Of Tumorigenicity 14 (ST14) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Suppression Of Tumorigenicity 14 (ST14) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Suppression Of Tumorigenicity 14 (ST14) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Suppression Of Tumorigenicity 14 (ST14) CLIA Kit Customized Service Offer
n/a ELISA Kit for Suppression Of Tumorigenicity 14 (ST14) ELISA Kit Customized Service Offer
  1. "Molecular cloning of cDNA for matriptase, a matrix-degrading serine protease with trypsin-like activity."J. Biol. Chem. 274:18231-18236(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Reverse biochemistry: use of macromolecular protease inhibitors to dissect complex biological processes and identify a membrane-type serine protease in epithelial cancer and normal tissue."Proc. Natl. Acad. Sci. U.S.A. 96:11054-11061(1999) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Purification and characterization of a complex containing matriptase and a Kunitz-type serine protease inhibitor from human milk."J. Biol. Chem. 274:18237-18242(1999) [PubMed] [Europe PMC] [Abstract]
  5. "Adhesion signaling by a novel mitotic substrate of src kinases."Oncogene 24:5333-5343(2005) [PubMed] [Europe PMC] [Abstract]
  6. "Protein interaction analysis of ST14 domains and their point and deletion mutants."J. Biol. Chem. 281:7406-7412(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Ichthyosis, follicular atrophoderma, and hypotrichosis caused by mutations in ST14 is associated with impaired profilaggrin processing."J. Invest. Dermatol. 129:862-869(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "Catalytic domain structures of MT-SP1/matriptase, a matrix-degrading transmembrane serine proteinase."J. Biol. Chem. 277:2160-2168(2002) [PubMed] [Europe PMC] [Abstract]
  10. "Autosomal recessive ichthyosis with hypotrichosis caused by a mutation in ST14, encoding type II transmembrane serine protease matriptase."Am. J. Hum. Genet. 80:467-477(2007) [PubMed] [Europe PMC] [Abstract]