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Succinate Coenzyme A Ligase, ADP Forming, Beta Subunit (SUCLA2)

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ATP-specific succinyl-CoA synthetase subunit beta; Renal carcinoma antigen NY-REN-39; Succinyl-CoA synthetase beta-A chain

Succinate Coenzyme A Ligase, ADP Forming, Beta Subunit (SUCLA2)
CCC P617
HGNC 11448
MGI 1306775
PubMed 17301081
RGD 1309397
UniProt Q9P2R7
Wiki SUCLA2
SUCLA2 encodes the beta-subunit of the ADP-forming succinyl-CoA synthetase (SCS-A; EC 6.2.1.5). SCS is a mitochondrial matrix enzyme that catalyzes the reversible synthesis of succinyl-CoA from succinate and CoA. The reverse reaction occurs in the Krebs cycle, while the forward reaction may produce succinyl-CoA for activation of ketone bodies and heme synthesis. GTP-specific (SCS-G; EC 6.2.1.4) and ATP-specific (SCS-A) isoforms of SCS catalyze GTP-dependent and ATP-dependent reactions, respectively. SCS is composed of an invariant alpha subunit and a beta subunit that determines the enzyme's nucleotide specificity.The predicted 411-amino acid human A-beta protein shares 89 to 95% identity with that of pigeon, mouse, and pig, and 38 to 48% identity with the beta subunit of bacterial SCSs.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Succinate Coenzyme A Ligase, ADP Forming, Beta Subunit (SUCLA2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Succinate Coenzyme A Ligase, ADP Forming, Beta Subunit (SUCLA2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Succinate Coenzyme A Ligase, ADP Forming, Beta Subunit (SUCLA2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Succinate Coenzyme A Ligase, ADP Forming, Beta Subunit (SUCLA2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Succinate Coenzyme A Ligase, ADP Forming, Beta Subunit (SUCLA2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Succinate Coenzyme A Ligase, ADP Forming, Beta Subunit (SUCLA2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Succinate Coenzyme A Ligase, ADP Forming, Beta Subunit (SUCLA2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Succinate Coenzyme A Ligase, ADP Forming, Beta Subunit (SUCLA2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Succinate Coenzyme A Ligase, ADP Forming, Beta Subunit (SUCLA2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Succinate Coenzyme A Ligase, ADP Forming, Beta Subunit (SUCLA2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Succinate Coenzyme A Ligase, ADP Forming, Beta Subunit (SUCLA2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Succinate Coenzyme A Ligase, ADP Forming, Beta Subunit (SUCLA2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Succinate Coenzyme A Ligase, ADP Forming, Beta Subunit (SUCLA2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Succinate Coenzyme A Ligase, ADP Forming, Beta Subunit (SUCLA2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Succinate Coenzyme A Ligase, ADP Forming, Beta Subunit (SUCLA2) ELISA Kit Customized Service Offer
  1. "Interaction between succinyl CoA synthetase and the heme-biosynthetic enzyme ALAS-E is disrupted in sideroblastic anemia."J. Clin. Invest. 105:757-764(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 13." Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Genetic evidence for the expression of ATP- and GTP-specific succinyl-CoA synthetases in multicellular eucaryotes."J. Biol. Chem. 273:27580-27586(1998) [PubMed] [Europe PMC] [Abstract]
  6. "Antigens recognized by autologous antibody in patients with renal-cell carcinoma."Int. J. Cancer 83:456-464(1999) [PubMed] [Europe PMC] [Abstract]
  7. "The major splice variant of human 5-aminolevulinate synthase-2 contributes significantly to erythroid heme biosynthesis."Int. J. Biochem. Cell Biol. 36:281-295(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Deficiency of the ADP-forming succinyl-CoA synthase activity is associated with encephalomyopathy and mitochondrial DNA depletion."Am. J. Hum. Genet. 76:1081-1086(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Mitochondrial encephalomyopathy with elevated methylmalonic acid is caused by SUCLA2 mutations."Brain 130:853-861(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  14. "SUCLA2 mutations are associated with mild methylmalonic aciduria, Leigh-like encephalomyopathy, dystonia and deafness."Brain 130:862-874(2007) [PubMed] [Europe PMC] [Abstract]
  15. "The novel mutation p.Asp251Asn in the beta-subunit of succinate-CoA ligase causes encephalomyopathy and elevated succinylcarnitine."J. Hum. Genet. 58:526-530(2013) [PubMed] [Europe PMC] [Abstract]