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Suppressor Of Ty 4 Homolog 1 (SUPT4H1)

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SUPT4H; SPT4H; Transcription elongation factor SPT4; DRB sensitivity-inducing factor 14 kDa subunit; DRB sensitivity-inducing factor small subunit

Suppressor Of Ty 4 Homolog 1 (SUPT4H1)
CCC P613
HGNC 11467
MGI 107416
PubMed 10075709
RGD 1306372
UniProt P63272
Wiki SUPT4H1
SUPT4H1 was expressed as 1.7- and 0.9-kb mRNAs in all human tissues tested. The 2 transcripts appeared to result from the use of alternative polyadenylation sites. The predicted 117-amino acid human protein is 42% identical to Spt4. Both proteins contain an N-terminal zinc finger motif. Using immunofluorescence, the authors found that epitope-tagged SUPT4H protein localized to the nucleus.
D-ribofuranosylbenzimidazole sensitivity-inducing factor (DSIF), a heterodimer of SPT4 and SPT5 (SUPT5H), repressed or activated transcription elongation by RNA polymerase II in HeLa cells based on the phosphorylation status of SPT5.when expressed in yeast, SUPT4H partially complemented all Spt4-null mutation phenotypes tested.

Organism species: Homo sapiens (Human)

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Organism species: Mus musculus (Mouse)

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Organism species: Rattus norvegicus (Rat)

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  1. "Isolation and characterization of the human and mouse homologues (SUPT4H and Supt4h) of the yeast SPT4 gene."Genomics 34:368-375(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Identification and analysis of a functional human homolog of the SPT4 gene of Saccharomyces cerevisiae."Mol. Cell. Biol. 16:2848-2856(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Evidence that P-TEFb alleviates the negative effect of DSIF on RNA polymerase II-dependent transcription in vitro."EMBO J. 17:7395-7403(1998) [PubMed] [Europe PMC] [Abstract]
  6. "DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs."Genes Dev. 12:343-356(1998) [PubMed] [Europe PMC] [Abstract]
  7. "NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation."Cell 97:41-51(1999) [PubMed] [Europe PMC] [Abstract]
  8. "Structure and function of the human transcription elongation factor DSIF."J. Biol. Chem. 274:8085-8092(1999) [PubMed] [Europe PMC] [Abstract]
  9. "Tat-SF1 protein associates with RAP30 and human SPT5 proteins."Mol. Cell. Biol. 19:5960-5968(1999) [PubMed] [Europe PMC] [Abstract]
  10. "FACT relieves DSIF/NELF-mediated inhibition of transcriptional elongation and reveals functional differences between P-TEFb and TFIIH."Mol. Cell 5:1067-1072(2000) [PubMed] [Europe PMC] [Abstract]
  11. "Domains in the SPT5 protein that modulate its transcriptional regulatory properties."Mol. Cell. Biol. 20:2970-2983(2000) [PubMed] [Europe PMC] [Abstract]
  12. "DSIF and NELF interact with RNA polymerase II elongation complex and HIV-1 Tat stimulates P-TEFb-mediated phosphorylation of RNA polymerase II and DSIF during transcription elongation."J. Biol. Chem. 276:12951-12958(2001) [PubMed] [Europe PMC] [Abstract]
  13. "A highly purified RNA polymerase II elongation control system."J. Biol. Chem. 276:42601-42609(2001) [PubMed] [Europe PMC] [Abstract]
  14. "Structure-function analysis of human Spt4: evidence that hSpt4 and hSpt5 exert their roles in transcriptional elongation as parts of the DSIF complex."Genes Cells 8:371-378(2003) [PubMed] [Europe PMC] [Abstract]
  15. "Methylation of SPT5 regulates its interaction with RNA polymerase II and transcriptional elongation properties."Mol. Cell 11:1055-1066(2003) [PubMed] [Europe PMC] [Abstract]
  16. "Locus-specific requirements for Spt5 in transcriptional activation and repression in Drosophila."Curr. Biol. 14:1680-1684(2004) [PubMed] [Europe PMC] [Abstract]
  17. "Human Spt6 stimulates transcription elongation by RNA polymerase II in vitro."Mol. Cell. Biol. 24:3324-3336(2004) [PubMed] [Europe PMC] [Abstract]
  18. "Functional interactions of RNA-capping enzyme with factors that positively and negatively regulate promoter escape by RNA polymerase II."Proc. Natl. Acad. Sci. U.S.A. 101:7572-7577(2004) [PubMed] [Europe PMC] [Abstract]
  19. "A negative elongation factor for human RNA polymerase II inhibits the anti-arrest transcript-cleavage factor TFIIS."Proc. Natl. Acad. Sci. U.S.A. 102:15036-15041(2005) [PubMed] [Europe PMC] [Abstract]
  20. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  21. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  22. "Crystal structure of the human transcription elongation factor DSIF hSpt4 subunit in complex with the hSpt5 dimerization interface."Biochem. J. 425:373-380(2010) [PubMed] [Europe PMC] [Abstract]