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Suppressor Of Variegation 3-9 Homolog 1 (SUV39H1)

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KMT1A; SUV39H; Histone-lysine N-methyltransferase SUV39H1; Histone H3-K9 methyltransferase 1; Lysine N-methyltransferase 1A; Position-effect variegation 3-9 homolog

Suppressor Of Variegation 3-9 Homolog 1 (SUV39H1)
CCC P612
HGNC 11479
MGI 1099440
PubMed 23340989
RGD 1565028
UniProt O43463
Wiki SUV39H1
SUV39H1 contains a chromodomain that is located close to the N terminus, a cysteine-rich region, an adjacent C-terminal SET domain that is followed at the very C-terminal tail by 3 conserved cysteine residues, and a putative nuclear localization signal. SUV39H1 shares 95% amino acid sequence identity with mouse Suv39h1, 42% identity with Drosophila Su(var)3-9, and 38% identity with S. pombe CLR4, another Su(var)3-9 ortholog. Immunoblot analysis of protein extracts from human cell lines detected an approximately 48-kD endogenous SUV39H1 protein, a mass that corresponds with the mass calculated from the SUV39H1 cDNA. Immunodetection of endogenous SUV39H1 protein revealed enriched distribution at heterochromatic foci during interphase and centromere-specific localization during metaphase.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Suppressor Of Variegation 3-9 Homolog 1 (SUV39H1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Suppressor Of Variegation 3-9 Homolog 1 (SUV39H1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Suppressor Of Variegation 3-9 Homolog 1 (SUV39H1) Polyclonal Antibody Customized Service Offer
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n/a ELISA Kit for Suppressor Of Variegation 3-9 Homolog 1 (SUV39H1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Suppressor Of Variegation 3-9 Homolog 1 (SUV39H1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Suppressor Of Variegation 3-9 Homolog 1 (SUV39H1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Suppressor Of Variegation 3-9 Homolog 1 (SUV39H1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Suppressor Of Variegation 3-9 Homolog 1 (SUV39H1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Suppressor Of Variegation 3-9 Homolog 1 (SUV39H1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Suppressor Of Variegation 3-9 Homolog 1 (SUV39H1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Suppressor Of Variegation 3-9 Homolog 1 (SUV39H1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Suppressor Of Variegation 3-9 Homolog 1 (SUV39H1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Suppressor Of Variegation 3-9 Homolog 1 (SUV39H1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Suppressor Of Variegation 3-9 Homolog 1 (SUV39H1) ELISA Kit Customized Service Offer
  1. "Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31."EMBO J. 18:1923-1938(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Mitotic phosphorylation of SUV39H1, a novel component of active centromeres, coincides with transient accumulation at mammalian centromeres."J. Cell Sci. 113:817-829(2000) [PubMed] [Europe PMC] [Abstract]
  6. "Regulation of chromatin structure by site-specific histone H3 methyltransferases."Nature 406:593-599(2000) [PubMed] [Europe PMC] [Abstract]
  7. "Set domain-dependent regulation of transcriptional silencing and growth control by SUV39H1, a mammalian ortholog of Drosophila Su(var)3-9."Mol. Cell. Biol. 20:4900-4909(2000) [PubMed] [Europe PMC] [Abstract]
  8. "Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins."Nature 410:116-120(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Rb targets histone H3 methylation and HP1 to promoters."Nature 412:561-565(2001) [PubMed] [Europe PMC] [Abstract]
  10. "Methyl-CpG binding domain 1 (MBD1) interacts with the Suv39h1-HP1 heterochromatic complex for DNA methylation-based transcriptional repression."J. Biol. Chem. 278:24132-24138(2003) [PubMed] [Europe PMC] [Abstract]
  11. "Selective interactions between vertebrate polycomb homologs and the SUV39H1 histone lysine methyltransferase suggest that histone H3-K9 methylation contributes to chromosomal targeting of Polycomb group proteins."Mol. Cell. Biol. 22:5539-5553(2002) [PubMed] [Europe PMC] [Abstract]
  12. "SUV39H1 interacts with AML1 and abrogates AML1 transactivity. AML1 is methylated in vivo."Oncogene 22:5229-5237(2003) [PubMed] [Europe PMC] [Abstract]
  13. "pRb2/p130-E2F4/5-HDAC1-SUV39H1-p300 and pRb2/p130-E2F4/5-HDAC1-SUV39H1-DNMT1 multimolecular complexes mediate the transcription of estrogen receptor-alpha in breast cancer."Oncogene 22:3511-3517(2003) [PubMed] [Europe PMC] [Abstract]
  14. "A Suv39h-dependent mechanism for silencing S-phase genes in differentiating but not in cycling cells."EMBO J. 23:605-615(2004) [PubMed] [Europe PMC] [Abstract]
  15. "Suv39h histone methyltransferases interact with Smads and cooperate in BMP-induced repression."Oncogene 23:5242-5251(2004) [PubMed] [Europe PMC] [Abstract]
  16. "A glue for heterochromatin maintenance: stable SUV39H1 binding to heterochromatin is reinforced by the SET domain."J. Cell Biol. 170:537-549(2005) [PubMed] [Europe PMC] [Abstract]
  17. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  18. "Gfi1b alters histone methylation at target gene promoters and sites of gamma-satellite containing heterochromatin."EMBO J. 25:2409-2419(2006) [PubMed] [Europe PMC] [Abstract]
  19. "The histone methyltransferase Suv39h1 increases class switch recombination specifically to IgA."J. Immunol. 177:1179-1188(2006) [PubMed] [Europe PMC] [Abstract]
  20. "Catalytic properties and kinetic mechanism of human recombinant Lys-9 histone H3 methyltransferase SUV39H1: participation of the chromodomain in enzymatic catalysis."Biochemistry 45:3272-3284(2006) [PubMed] [Europe PMC] [Abstract]
  21. "Histone methyltransferase Suv39h1 represses MyoD-stimulated myogenic differentiation."EMBO J. 25:3323-3334(2006) [PubMed] [Europe PMC] [Abstract]
  22. "Recruitment of the histone methyltransferase SUV39H1 and its role in the oncogenic properties of the leukemia-associated PML-retinoic acid receptor fusion protein."Mol. Cell. Biol. 26:1288-1296(2006) [PubMed] [Europe PMC] [Abstract]
  23. "RUNX1 associates with histone deacetylases and SUV39H1 to repress transcription."Oncogene 25:5777-5786(2006) [PubMed] [Europe PMC] [Abstract]
  24. "SUV39H1 interacts with HTLV-1 Tax and abrogates Tax transactivation of HTLV-1 LTR."Retrovirology 3:5-5(2006) [PubMed] [Europe PMC] [Abstract]
  25. "SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation."Nature 450:440-444(2007) [PubMed] [Europe PMC] [Abstract]
  26. "Epigenetic control of rDNA loci in response to intracellular energy status."Cell 133:627-639(2008) [PubMed] [Europe PMC] [Abstract]
  27. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  28. "Inhibition of SUV39H1 methyltransferase activity by DBC1."J. Biol. Chem. 284:10361-10366(2009) [PubMed] [Europe PMC] [Abstract]
  29. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  30. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  31. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  32. "Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model."Nat. Commun. 4:1868-1868(2013) [PubMed] [Europe PMC] [Abstract]