≡

Transcription Factor 7 Like Protein 1 (TCF7L1)

[Edit]

TCF3; HMG box transcription factor 3

Transcription Factor 7 Like Protein 1 (TCF7L1)
CCC P602
HGNC 11640
MGI 1202876
PubMed 23810553
RGD 1311671
UniProt Q9HCS4
Wiki TCF7L1
TCF7L1 was occasionally upregulated in primary gastric cancer compared with normal gastric mucosa.TCF/LEF transcription factors, such as TCF7L1, are mediators of the Wnt signaling pathway and are antagonized by the TGF-beta (TGFB1) signaling pathway.
The deduced 588-amino acid protein contains a beta-catenin (CTNNB1)-binding domain at its N terminus, followed by an HMG box, a nuclear translocation signal, and 2 putative CTBP-binding sites at its C terminus. TCF7L1 shares 58% amino acid identity with TCF7L2, its closest homolog among human TCF proteins. Northern blot analysis detected a 3.0-kb TCF7L1 transcript in human stomach and in some human gastric cancer cell lines.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transcription Factor 7 Like Protein 1 (TCF7L1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transcription Factor 7 Like Protein 1 (TCF7L1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transcription Factor 7 Like Protein 1 (TCF7L1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transcription Factor 7 Like Protein 1 (TCF7L1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transcription Factor 7 Like Protein 1 (TCF7L1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transcription Factor 7 Like Protein 1 (TCF7L1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transcription Factor 7 Like Protein 1 (TCF7L1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transcription Factor 7 Like Protein 1 (TCF7L1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transcription Factor 7 Like Protein 1 (TCF7L1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transcription Factor 7 Like Protein 1 (TCF7L1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transcription Factor 7 Like Protein 1 (TCF7L1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transcription Factor 7 Like Protein 1 (TCF7L1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transcription Factor 7 Like Protein 1 (TCF7L1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transcription Factor 7 Like Protein 1 (TCF7L1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transcription Factor 7 Like Protein 1 (TCF7L1) ELISA Kit Customized Service Offer
  1. "Mitomycin C resistance induced by TCF-3 overexpression in gastric cancer cell line MKN28 is associated with DT-diaphorase down-regulation."Cancer Res. 60:5959-5962(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "A gene family of HMG-box transcription factors with homology to TCF-1."Nucleic Acids Res. 20:611-611(1992) [PubMed] [Europe PMC] [Abstract]
  5. "Restricted high level expression of Tcf-4 protein in intestinal and mammary gland epithelium."Am. J. Pathol. 154:29-35(1999) [PubMed] [Europe PMC] [Abstract]
  6. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]