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Transcription Factor 7 Like Protein 2 (TCF7L2)

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TCF4; HMG box transcription factor 4

Transcription Factor 7 Like Protein 2 (TCF7L2)
CCC P601
HGNC 11641
MGI 1202879
PubMed 19602480
RGD 1583621
UniProt Q9NQB0
Wiki TCF7L2
TCF7L2 encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes.TCF7L1 and TCF7L2 were not expressed in cells of the lymphoid lineage. The deduced amino acid sequences of the HMG boxes of TCF7L1, TCF7L2, and TCF7 show striking homology. That gene activation by the beta-catenin/TCF4 complex is a critical event in cancer development is indicated by the fact that a subset of colorectal cancers that lack somatic mutations in APC show somatic mutations in the beta-catenin gene. These mutations are presumed to render beta-catenin insensitive to regulation by APC and GSK3B.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transcription Factor 7 Like Protein 2 (TCF7L2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transcription Factor 7 Like Protein 2 (TCF7L2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transcription Factor 7 Like Protein 2 (TCF7L2) Polyclonal Antibody Customized Service Offer
Assay Kits SEP601Hu ELISA Kit for Transcription Factor 7 Like Protein 2 (TCF7L2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transcription Factor 7 Like Protein 2 (TCF7L2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transcription Factor 7 Like Protein 2 (TCF7L2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transcription Factor 7 Like Protein 2 (TCF7L2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transcription Factor 7 Like Protein 2 (TCF7L2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transcription Factor 7 Like Protein 2 (TCF7L2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transcription Factor 7 Like Protein 2 (TCF7L2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transcription Factor 7 Like Protein 2 (TCF7L2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transcription Factor 7 Like Protein 2 (TCF7L2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transcription Factor 7 Like Protein 2 (TCF7L2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transcription Factor 7 Like Protein 2 (TCF7L2) ELISA Kit Customized Service Offer
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  11. "All Tcf HMG box transcription factors interact with Groucho-related co-repressors."Nucleic Acids Res. 29:1410-1419(2001) [PubMed] [Europe PMC] [Abstract]
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  17. "Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes." Nat. Genet. 38:320-323(2006) [PubMed] [Europe PMC] [Abstract]
  18. "The C/EBP homologous protein CHOP (GADD153) is an inhibitor of Wnt/TCF signals."Oncogene 25:3397-3407(2006) [PubMed] [Europe PMC] [Abstract]
  19. "Coiled-coil domain containing 85B suppresses the beta-catenin activity in a p53-dependent manner."Oncogene 27:1520-1526(2008) [PubMed] [Europe PMC] [Abstract]
  20. "The kinase TNIK is an essential activator of Wnt target genes."EMBO J. 28:3329-3340(2009) [PubMed] [Europe PMC] [Abstract]
  21. "MAD2B, a novel TCF4-binding protein, modulates TCF4-mediated epithelial-mesenchymal transdifferentiation."J. Biol. Chem. 284:19613-19622(2009) [PubMed] [Europe PMC] [Abstract]
  22. "Zipper-interacting protein kinase (ZIPK) modulates canonical Wnt/beta-catenin signaling through interaction with Nemo-like kinase and T-cell factor 4 (NLK/TCF4)."J. Biol. Chem. 286:19170-19177(2011) [PubMed] [Europe PMC] [Abstract]
  23. "Kindlin 2 forms a transcriptional complex with beta-catenin and TCF4 to enhance Wnt signalling."EMBO Rep. 13:750-758(2012) [PubMed] [Europe PMC] [Abstract]
  24. "Beta-catenin inhibits promyelocytic leukemia protein tumor suppressor function in colorectal cancer cells."Gastroenterology 142:572-581(2012) [PubMed] [Europe PMC] [Abstract]
  25. "SPINDLIN1 promotes cancer cell proliferation through activation of WNT/TCF-4 signaling."Mol. Cancer Res. 10:326-335(2012) [PubMed] [Europe PMC] [Abstract]
  26. "XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling."Mol. Cell 45:619-628(2012) [PubMed] [Europe PMC] [Abstract]
  27. "Molecular basis underlying histone H3 lysine-arginine methylation pattern readout by Spin/Ssty repeats of Spindlin1."Genes Dev. 28:622-636(2014) [PubMed] [Europe PMC] [Abstract]
  28. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  29. "Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico."Nature 506:97-101(2014) [PubMed] [Europe PMC] [Abstract]
  30. "Tcf4 can specifically recognize beta-catenin using alternative conformations."Nat. Struct. Biol. 8:1048-1052(2001) [PubMed] [Europe PMC] [Abstract]
  31. "Structure of a human Tcf4-beta-catenin complex."Nat. Struct. Biol. 8:1053-1057(2001) [PubMed] [Europe PMC] [Abstract]
  32. "Crystal structure of a beta-catenin/BCL9/Tcf4 complex."Mol. Cell 24:293-300(2006) [PubMed] [Europe PMC] [Abstract]
  33. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]