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T-Cell Leukemia Translocation Altered Gene (TCTA)

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T-Cell Leukemia Translocation Altered Gene (TCTA)
CCC P595
HGNC 11692
MGI 1918829
PubMed 23143845
RGD 1359333
UniProt P57738
Aplan et al. (1995) cloned a gene at the site of a t(1;3)(p34;p21) translocation breakpoint in T-cell acute lymphoblastic leukemia. A cDNA for the gene, designated TCTA (T-cell leukemia translocation-associated gene), was identified from a human bone marrow library. The cDNA has a short open reading frame of 103 amino acids. Northern blots showed the gene was expressed ubiquitously with highest levels in the kidney.
TCTA, located at 3p21, is deleted in a subset of small cell lung cancer (SCLC) cell lines. By comparative Southern blotting the authors detected related sequences in the DNA of other mammals, chicken and Drosophila.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant T-Cell Leukemia Translocation Altered Gene (TCTA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to T-Cell Leukemia Translocation Altered Gene (TCTA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to T-Cell Leukemia Translocation Altered Gene (TCTA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for T-Cell Leukemia Translocation Altered Gene (TCTA) CLIA Kit Customized Service Offer
n/a ELISA Kit for T-Cell Leukemia Translocation Altered Gene (TCTA) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant T-Cell Leukemia Translocation Altered Gene (TCTA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to T-Cell Leukemia Translocation Altered Gene (TCTA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to T-Cell Leukemia Translocation Altered Gene (TCTA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for T-Cell Leukemia Translocation Altered Gene (TCTA) CLIA Kit Customized Service Offer
n/a ELISA Kit for T-Cell Leukemia Translocation Altered Gene (TCTA) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant T-Cell Leukemia Translocation Altered Gene (TCTA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to T-Cell Leukemia Translocation Altered Gene (TCTA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to T-Cell Leukemia Translocation Altered Gene (TCTA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for T-Cell Leukemia Translocation Altered Gene (TCTA) CLIA Kit Customized Service Offer
n/a ELISA Kit for T-Cell Leukemia Translocation Altered Gene (TCTA) ELISA Kit Customized Service Offer
  1. "Cloning and characterization of TCTA, a gene located at the site of a t(1;3) translocation."Cancer Res. 55:1917-1921(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "T-cell leukemia translocation-associated gene (TCTA) protein is required for human osteoclastogenesis."Bone 45:627-639(2009) [PubMed] [Europe PMC] [Abstract]