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Vacuolar Protein Sorting 33B (VPS33B)

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Vacuolar protein sorting-associated protein 33B

Vacuolar Protein Sorting 33B (VPS33B)
CCC P558
HGNC 12712
MGI 2446237
PubMed 16492441
RGD 620644
UniProt Q9H267
Wiki VPS33B
VPS33B is a member of the Sec-1 domain family, and encodes the human ortholog of rat Vps33b which is homologous to the yeast class C Vps33 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. The deduced 617-amino acid protein has a calculated molecular mass of 70.6 kD. VPS33B shares 96% amino acid identity with rat Vps33b. Homologous proteins were identified in insect, nematode, plant, and yeast databases. Northern blot analysis of 8 tissues detected VPS33B mRNA above the 2.4-kb marker. VPS33B was highly enriched in testis and less abundant in all other tissues.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Vacuolar Protein Sorting 33B (VPS33B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Vacuolar Protein Sorting 33B (VPS33B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Vacuolar Protein Sorting 33B (VPS33B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Vacuolar Protein Sorting 33B (VPS33B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Vacuolar Protein Sorting 33B (VPS33B) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Vacuolar Protein Sorting 33B (VPS33B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Vacuolar Protein Sorting 33B (VPS33B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Vacuolar Protein Sorting 33B (VPS33B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Vacuolar Protein Sorting 33B (VPS33B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Vacuolar Protein Sorting 33B (VPS33B) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Vacuolar Protein Sorting 33B (VPS33B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Vacuolar Protein Sorting 33B (VPS33B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Vacuolar Protein Sorting 33B (VPS33B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Vacuolar Protein Sorting 33B (VPS33B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Vacuolar Protein Sorting 33B (VPS33B) ELISA Kit Customized Service Offer
  1. "Cloning, mapping and expression analysis of VPS33B, the human orthologue of rat Vps33b."Cytogenet. Cell Genet. 89:92-95(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning and characterization of human VPS18, VPS11, VPS16, and VPS33."Gene 264:241-247(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Mycobacterium tuberculosis virulence is mediated by PtpA dephosphorylation of human vacuolar protein sorting 33B."Cell Host Microbe 3:316-322(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Mutations in VIPAR cause an arthrogryposis, renal dysfunction and cholestasis syndrome phenotype with defects in epithelial polarization." Nat. Genet. 42:303-312(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "Mutations in VPS33B, encoding a regulator of SNARE-dependent membrane fusion, cause arthrogryposis-renal dysfunction-cholestasis (ARC) syndrome." Nat. Genet. 36:400-404(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Molecular investigations to improve diagnostic accuracy in patients with ARC syndrome." Hum. Mutat. 30:E330-E337(2009) [PubMed] [Europe PMC] [Abstract]