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WNT10B is a member of the WNT gene family. It may be involved in breast cancer, and its protein signaling is likely a molecular switch that governs adipogenesis. This protein is 96% identical to the mouse Wnt10b protein at the amino acid level. This gene is clustered with another family member, WNT1, in the chromosome 12q13 region.
The human WNT10B sequence is 88% and 95% identical to the mouse gene at nucleotide and amino acid levels, respectively. WNT10B expression was not observed in normal and benign proliferations of human breast tissue but was found to be elevated in 3 of 50 primary breast carcinomas. Southern blot analysis of the carcinoma expressing the highest level of WNT10B showed no amplification or rearrangement of the gene.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPP553Hu01 | Recombinant Wingless Type MMTV Integration Site Family, Member 10B (WNT10B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAP553Hu01 | Polyclonal Antibody to Wingless Type MMTV Integration Site Family, Member 10B (WNT10B) | WB; IHC |
| MAP553Hu21 | Monoclonal Antibody to Wingless Type MMTV Integration Site Family, Member 10B (WNT10B) | WB; IHC; ICC; IP. | |
| Assay Kits | SEP553Hu | ELISA Kit for Wingless Type MMTV Integration Site Family, Member 10B (WNT10B) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCP553Hu | CLIA Kit for Wingless Type MMTV Integration Site Family, Member 10B (WNT10B) | Chemiluminescent immunoassay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPP553Mu01 | Recombinant Wingless Type MMTV Integration Site Family, Member 10B (WNT10B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPP553Mu02 | Recombinant Wingless Type MMTV Integration Site Family, Member 10B (WNT10B) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAP553Mu01 | Polyclonal Antibody to Wingless Type MMTV Integration Site Family, Member 10B (WNT10B) | WB; IHC; ICC; IP. |
| PAP553Mu02 | Polyclonal Antibody to Wingless Type MMTV Integration Site Family, Member 10B (WNT10B) | WB; IHC; ICC; IP. | |
| Assay Kits | SEP553Mu | ELISA Kit for Wingless Type MMTV Integration Site Family, Member 10B (WNT10B) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCP553Mu | CLIA Kit for Wingless Type MMTV Integration Site Family, Member 10B (WNT10B) | Chemiluminescent immunoassay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Wingless Type MMTV Integration Site Family, Member 10B (WNT10B) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Wingless Type MMTV Integration Site Family, Member 10B (WNT10B) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Wingless Type MMTV Integration Site Family, Member 10B (WNT10B) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Wingless Type MMTV Integration Site Family, Member 10B (WNT10B) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Wingless Type MMTV Integration Site Family, Member 10B (WNT10B) | ELISA Kit Customized Service Offer |
- "Isolation, characterization and chromosomal localization of human WNT10B."Cytogenet. Cell Genet. 77:278-282(1997) [PubMed] [Europe PMC] [Abstract]
- "Proto-oncogene WNT10B is up-regulated by tumor necrosis factor alpha in human gastric cancer cell line MKN45."Int. J. Oncol. 19:1187-1192(2001) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "A novel human Wnt gene, WNT10B, maps to 12q13 and is expressed in human breast carcinomas."Oncogene 14:1249-1253(1997) [PubMed] [Europe PMC] [Abstract]
- "Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21."Genomics 46:450-458(1997) [PubMed] [Europe PMC] [Abstract]
- "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
- "WNT10B mutations in human obesity."Diabetologia 49:678-684(2006) [PubMed] [Europe PMC] [Abstract]
- "Homozygous WNT10b mutation and complex inheritance in Split-Hand/Foot Malformation."Hum. Mol. Genet. 17:2644-2653(2008) [PubMed] [Europe PMC] [Abstract]