≡

Tripartite Motif Containing Protein 25 (TRIM25)

[Edit]

EFP; RNF147; Estrogen-Responsive Finger Protein; E3 ubiquitin/ISG15 ligase TRIM25; Ubiquitin/ISG15-conjugating enzyme TRIM25; RING finger protein 147; Zinc finger protein 147

Tripartite Motif Containing Protein 25 (TRIM25)
CCC P517
HGNC 12932
MGI 102749
PubMed 21292167
RGD 1594396
UniProt Q14258
Wiki TRIM25
TRIM25 is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The presence of potential DNA-binding and dimerization-transactivation domains suggests that this protein may act as a transcription factor, similar to several other members of the TRIM family. Expression of the gene is upregulated in response to estrogen, and it is thought to mediate estrogen actions in breast cancer as a primary response gene. EFP is a RING-finger-dependent ubiquitin ligase (E3) that targets proteolysis of 14-3-3-sigma, a negative cell cycle regulator that causes G2 arrest. Tumor growth of breast cancer MCF7 cells implanted in female athymic mice is reduced by treatment with antisense Efp oligonucleotide.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tripartite Motif Containing Protein 25 (TRIM25) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tripartite Motif Containing Protein 25 (TRIM25) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tripartite Motif Containing Protein 25 (TRIM25) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tripartite Motif Containing Protein 25 (TRIM25) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tripartite Motif Containing Protein 25 (TRIM25) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tripartite Motif Containing Protein 25 (TRIM25) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tripartite Motif Containing Protein 25 (TRIM25) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tripartite Motif Containing Protein 25 (TRIM25) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tripartite Motif Containing Protein 25 (TRIM25) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tripartite Motif Containing Protein 25 (TRIM25) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tripartite Motif Containing Protein 25 (TRIM25) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tripartite Motif Containing Protein 25 (TRIM25) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tripartite Motif Containing Protein 25 (TRIM25) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tripartite Motif Containing Protein 25 (TRIM25) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tripartite Motif Containing Protein 25 (TRIM25) ELISA Kit Customized Service Offer
  1. "Genomic binding-site cloning reveals an estrogen-responsive gene that encodes a RING finger protein."Proc. Natl. Acad. Sci. U.S.A. 90:11117-11121(1993) [PubMed] [Europe PMC] [Abstract]
  2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Systemic distribution of estrogen-responsive finger protein (Efp) in human tissues."Mol. Cell. Endocrinol. 218:147-153(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
  6. "A ubiquitin E3 ligase Efp is up-regulated by interferons and conjugated with ISG15."Biochem. Biophys. Res. Commun. 351:540-546(2006) [PubMed] [Europe PMC] [Abstract]
  7. "The interferon-inducible ubiquitin-protein isopeptide ligase (E3) EFP also functions as an ISG15 E3 ligase."J. Biol. Chem. 281:3989-3994(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Negative regulation of ISG15 E3 ligase EFP through its autoISGylation."Biochem. Biophys. Res. Commun. 354:321-327(2007) [PubMed] [Europe PMC] [Abstract]
  9. "TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity."Nature 446:916-920(2007) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I."Cell Host Microbe 5:439-449(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  16. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]