Zinc Finger Protein 18 (ZNF18)

A zinc finger protein is a DNA-binding protein domain consisting of zinc fingers ranging from two in the Drosophila regulator ADR1, the more common three in mammalian Sp1 up to nine in TF_IIIA. Zinc finger proteins are regulatory transcription factors that interact directly with DNA and/or RNA.

Among the different human Kox cDNAs encoding zinc finger structures isolated from cell lines of T cell origin, Rousseau-Merck et al. (1991, 1993) demonstrated that ZNF18 (Kox 11) maps to 17p13-p12 in the same region as ZNF29 and TP53. ZFP3 maps to the same region. Mapping was performed by analysis of somatic cell hybrids and in situ hybridization. From somatic cell hybrid analysis, Huebner et al. (1991) concluded that the order is 17pter--TP53, ZNF18--ZNF29--p12.