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Zinc Finger Protein 224 (ZNF224)

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ZNF255; ZNF27; BMZF-2; KOX22; Bone marrow zinc finger 2

Zinc Finger Protein 224 (ZNF224)
CCC P486
HGNC 13017
PubMed 20587513
UniProt Q9NZL3
Wiki ZNF224
The deduced 623-amino acid ZNF224 protein contains 18 tandemly repeated C-terminal zinc finger motifs with interspersed conserved knuckle sequences, as well as an N-terminal Kruppel-related novel box (KRNB), which is also found in FDZF2 (ZNF230). RT-PCR analysis detected wide expression that was highest in hemopoietic tissues and cell lines.
The deduced 622-amino acid protein has a calculated molecular mass of 72 kD. Northern blot analysis detected expression only in fetal tissues. Transcripts of about 5.0 and 4.0 were detected in fetal brain, lung, liver, and kidney, and a transcript of about 3.4 kb was also detected in fetal lung. Western blot analysis of cytosolic and nuclear fractions obtained from transfected cells indicated that ZNF224 is expressed in the nucleus.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger Protein 224 (ZNF224) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger Protein 224 (ZNF224) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger Protein 224 (ZNF224) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger Protein 224 (ZNF224) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger Protein 224 (ZNF224) ELISA Kit Customized Service Offer
  1. "Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters."Genome Res. 13:1097-1110(2003) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Molecular cloning of six novel Kruppel-like zinc finger genes from hematopoietic cells and identification of a novel transregulatory domain KRNB."J. Biol. Chem. 274:35741-35748(1999) [PubMed] [Europe PMC] [Abstract]
  5. "Inhibition of Wilms tumor 1 transactivation by bone marrow zinc finger 2, a novel transcriptional repressor."J. Biol. Chem. 277:44826-44837(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Multiple genes encoding zinc finger domains are expressed in human T cells."New Biol. 2:363-374(1990) [PubMed] [Europe PMC] [Abstract]
  7. "Cell-permeable peptide DEPDC1-ZNF224 interferes with transcriptional repression and oncogenicity in bladder cancer cells."Cancer Res. 70:5829-5839(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1."Cell. Mol. Life Sci. 70:3947-3958(2013) [PubMed] [Europe PMC] [Abstract]
  9. "Solution structure of the ZF-C2H2 domain from human zinc finger protein 224."Submitted (OCT-2007) to the PDB data bank