Zinc Finger Protein 254 (ZNF254)

Zinc finger proteins have been shown to interact with nucleic acids and to have diverse functions. The zinc finger domain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines that are involved in coordinating zinc. Kruppel-related proteins form 1 family of zinc finger proteins.

The full-length ZNF254 coding sequence encodes a 353-amino acid protein with sequence similarity to the Kruppel-related zinc finger protein HTF10, or ZNF91. The ZNF254 protein has 4 tandemly repeated C-terminal zinc finger motifs with interspersed conserved knuckle sequences, as well as an N-terminal Kruppel-associated box (KRAB). RT-PCR analysis detected variable expression of ZNF254 that was highest in monocytic cell lines.