Zinc Finger Protein 34 (ZNF34)

A zinc finger protein is a DNA-binding protein domain consisting of zinc fingers ranging from two in the Drosophila regulator ADR1, the more common three in mammalian Sp1 up to nine in TF_IIIA.

KOX32 is a 1.4-kb cDNA fragment of the ZNF34 zinc finger gene cloned into the EcoRI site of a plasmid vector. La Pillo et al. (1993) described a BanII RFLP in the ZNF34 gene.Huebner et al. (1991) mapped the ZNF34 gene to chromosome 8q24, proximal to MYC by somatic cell hybrid analysis and in situ chromosomal hybridization. Since MYC is located in 8q24.12-q24.13 and both genes were found to be intact in 2 patients with Langer-Giedion syndrome and a deletion of 8q22.3-q24.11 and 8q23.3-q24.12, respectively, La Pillo et al. (1993) concluded that ZNF34 is located in 8q24.12-q24.13.