Zinc Finger Protein 80 (ZNF80)

Zinc finger proteins have been shown to interact with nucleic acids and to have diverse functions, such as stimulation of transcription, transcriptional repression, binding to single-stranded DNA, binding to RNA, or bifunctional DNA- and RNA-binding activities. The zinc finger domain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines that are involved in coordinating zinc. Zinc fingers bind divalent zinc ions by 1 of at least 5 different combinations of cysteines and histidines, including the eukaryotic C2H2, C4, and C6 motifs. The Drosophila protein Kruppel belongs to a very large family of related C2H2 zinc finger proteins in which the zinc finger motifs are located in smaller or larger tandem arrays.Huebner et al. (1993) mapped the ZNF80 gene to chromosome 3p12-qter by analysis of its segregation pattern in a rodent/human hybrid panel.