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Zinc Finger Protein 91 (ZNF91)

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HPF7; HTF10

Zinc Finger Protein 91 (ZNF91)
CCC P446
HGNC 13166
PubMed 10335408
UniProt Q05481
The ZNF91 gene encodes a zinc finger protein of the KRAB (Kruppel-associated box) subfamily. It encodes a predicted 1,182-amino acid protein containing an N-terminal KRAB domain, which includes the KRAB A and KRAB B modules, and 35 contiguous finger repeats separated by Kruppel-like H/C link sequences.
The KRAB domain and finger cluster are connected by a 92-amino acid spacer element that is conserved in a subset of KRAB zinc finger proteins; the authors stated that this spacer region defines the ZNF91 subfamily. Northern blot analysis detected a 4.4-kb ZNF91 transcript in all human tissues tested, with the highest levels found in T-lymphoid cells.each KRAB module of ZNF91 is encoded by a separate exon, and the zinc finger domain by a single exon.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger Protein 91 (ZNF91) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger Protein 91 (ZNF91) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger Protein 91 (ZNF91) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger Protein 91 (ZNF91) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger Protein 91 (ZNF91) ELISA Kit Customized Service Offer
  1. "Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells."EMBO J. 12:1363-1374(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The evolutionarily conserved Kruppel-associated box domain defines a subfamily of eukaryotic multifingered proteins."Proc. Natl. Acad. Sci. U.S.A. 88:3608-3612(1991) [PubMed] [Europe PMC] [Abstract]
  5. "Emergence of the ZNF91 Kruppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea."Proc. Natl. Acad. Sci. U.S.A. 92:10757-10761(1995) [PubMed] [Europe PMC] [Abstract]
  6. "Characterization of the human Fc gamma RIIB gene promoter: human zinc-finger proteins (ZNF140 and ZNF91) that bind to different regions function as transcription repressors."Int. Immunol. 13:1075-1084(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Evolutionary expansion and divergence in the ZNF91 subfamily of primate-specific zinc finger genes."Genome Res. 16:584-594(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1."Cell. Mol. Life Sci. 70:3947-3958(2013) [PubMed] [Europe PMC] [Abstract]
  9. "An evolutionary arms race between KRAB zinc-finger genes ZNF91/93 and SVA/L1 retrotransposons."Nature 516:242-245(2014) [PubMed] [Europe PMC] [Abstract]