Zinc Finger Protein 99 (ZNF99)

Zinc finger proteins (ZNFs), which bind nucleic acids, perform many key functions, the most important of which is regulating transcription. A zinc finger protein is a DNA-binding protein domain consisting of zinc fingers ranging from two in the Drosophila regulator ADR1, the more common three in mammalian Sp1 up to nine in TF_IIIA.

Using probes derived from a ZNF91 cDNA to screen a pool of human chromosome 19-specific cosmids that had hybridized to a degenerate oligonucleotide corresponding to the H/C link region, Bellefroid et al. (1993) isolated the genes of several distinct ZNF91 subfamily members, including ZNF99. They found that ZNF91-related genes are widely expressed in human tissues, with the highest expression in T-lymphoid cells.