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KCNQ1 Downstream Neighbor (KCNQ1DN)

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BWRT; Beckwith-Wiedemann Region Transcript Protein

KCNQ1 Downstream Neighbor (KCNQ1DN)
CCC P424
HGNC 13335
PubMed 11056398
UniProt Q9H478
Wiki KCNQ1DN
Imprinting is a phenomenon in which epigenetic modifications lead to expression or suppression of alleles of some genes based on their parental origin. Wilms tumor-2 (WT2) is defined by maternal-specific loss of heterozygosity of a critical region on chromosome 11p15.5 that includes several imprinted genes. KCNQ1DN is an imprinted gene located within the WT2 critical region that is expressed from the maternal allele.
KCNQ1DN has a small ORF encoding 68 amino acids, but it lacks a Kozak consensus sequence around the initiator ATG, suggesting it is not translated. KCNQ1DN expression was present in fetal kidney between 82 and 103 days of gestation. RT-PCR showed monoallelic expression of KCNQ1DN in fetal kidney and maternal expression of KCNQ1DN in placenta.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant KCNQ1 Downstream Neighbor (KCNQ1DN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to KCNQ1 Downstream Neighbor (KCNQ1DN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to KCNQ1 Downstream Neighbor (KCNQ1DN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for KCNQ1 Downstream Neighbor (KCNQ1DN) CLIA Kit Customized Service Offer
n/a ELISA Kit for KCNQ1 Downstream Neighbor (KCNQ1DN) ELISA Kit Customized Service Offer
  1. "Sequence and functional comparison in the Beckwith-Wiedemann region: implications for a novel imprinting centre and extended imprinting."Hum. Mol. Genet. 9:2691-2706(2000) [PubMed] [Europe PMC] [Abstract]
  2. "A novel imprinted gene, KCNQ1DN, within the WT2 critical region of human chromosome 11p15.5 and its reduced expression in Wilms' tumors."J. Biochem. 128:847-853(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]