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Membrane Spanning 4 Domains Subfamily A, Member 12 (MS4A12)

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Ms4a10

Membrane Spanning 4 Domains Subfamily A, Member 12 (MS4A12)
CCC P421
HGNC 13370
MGI 2685812
PubMed 18451174
RGD 1307162
UniProt Q9NXJ0
MS4A12 is a cell surface protein found primarily in the apical membrane of colonocytes. Silencing of this gene in colon cancer cells inhibits the proliferation, cell motility, and chemotactic invasion of cells. This gene is part of a cluster of similar genes found on chromosome 11. Two transcript variants encoding different isoforms have been found for this gene.
By database searching for homologs of CD20 (MS4A1), Liang and Tedder (2001) obtained a cDNA encoding MS4A12. The predicted 267-amino acid protein is 60% identical to the pig homolog. PCR analysis detected no expression of MS4A12 in cDNA from multiple hemopoietic cell lines, but an EST was isolated from colon.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Membrane Spanning 4 Domains Subfamily A, Member 12 (MS4A12) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Membrane Spanning 4 Domains Subfamily A, Member 12 (MS4A12) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Membrane Spanning 4 Domains Subfamily A, Member 12 (MS4A12) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Membrane Spanning 4 Domains Subfamily A, Member 12 (MS4A12) CLIA Kit Customized Service Offer
n/a ELISA Kit for Membrane Spanning 4 Domains Subfamily A, Member 12 (MS4A12) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Membrane Spanning 4 Domains Subfamily A, Member 12 (MS4A12) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Membrane Spanning 4 Domains Subfamily A, Member 12 (MS4A12) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Membrane Spanning 4 Domains Subfamily A, Member 12 (MS4A12) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Membrane Spanning 4 Domains Subfamily A, Member 12 (MS4A12) CLIA Kit Customized Service Offer
n/a ELISA Kit for Membrane Spanning 4 Domains Subfamily A, Member 12 (MS4A12) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Membrane Spanning 4 Domains Subfamily A, Member 12 (MS4A12) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Membrane Spanning 4 Domains Subfamily A, Member 12 (MS4A12) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Membrane Spanning 4 Domains Subfamily A, Member 12 (MS4A12) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Membrane Spanning 4 Domains Subfamily A, Member 12 (MS4A12) CLIA Kit Customized Service Offer
n/a ELISA Kit for Membrane Spanning 4 Domains Subfamily A, Member 12 (MS4A12) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes." Genome Res. 16:55-65(2006) [PubMed] [Europe PMC] [Abstract]