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Fc Fragment Of IgG Binding Protein (FcgBP)

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FC(GAMMA)BP; IgG Fc Binding Protein; Human Fc Gamma BP; Fcgamma-binding protein antigen

Fc Fragment Of IgG Binding Protein (FcgBP)
CCC P389
HGNC 13572
MGI 2444336
PubMed 9182547
UniProt Q9Y6R7
Wiki FCGBP
Cloning a cDNA for human IgGFc binding protein (FcgammaBP) from human colonic epithelial cells reveals an mRNA and coding region of 17 and 16.2 kilobases, respectively. The predicted amino acid sequence contains 12 occurrences of a 400-amino acid cysteine-rich unit resembling that found in mucin. A motif (CGLCGN) in FcgammaBP is conserved in MUC2 and prepro-von Willebrand factor.
The N-terminal 450-amino acid sequences are necessary and sufficient to confer IgG Fc binding activity. FcgammaBP mRNA is expressed only in placenta and colonic epithelial cells. These results suggest that FcgammaBP may play an important role in immune protection and inflammation in the intestines of primates.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP389Hu01 Recombinant Fc Fragment Of IgG Binding Protein (FcgBP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAP389Hu01 Polyclonal Antibody to Fc Fragment Of IgG Binding Protein (FcgBP) WB; IHC; ICC; IP.
MAP389Hu21 Monoclonal Antibody to Fc Fragment Of IgG Binding Protein (FcgBP) WB; IHC; ICC; IP.
Assay Kits SEP389Hu ELISA Kit for Fc Fragment Of IgG Binding Protein (FcgBP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Fc Fragment Of IgG Binding Protein (FcgBP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Fc Fragment Of IgG Binding Protein (FcgBP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Fc Fragment Of IgG Binding Protein (FcgBP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Fc Fragment Of IgG Binding Protein (FcgBP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fc Fragment Of IgG Binding Protein (FcgBP) ELISA Kit Customized Service Offer
  1. "Human IgGFc binding protein (FcgammaBP) in colonic epithelial cells exhibits mucin-like structure."J. Biol. Chem. 272:15232-15241(1997) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Detection of Fcgamma binding protein antigen in human sera and its relation with autoimmune diseases."Immunol. Lett. 79:229-235(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Differential expression of IgG Fc binding protein (FcgammaBP) in human normal thyroid tissue, thyroid adenomas and thyroid carcinomas."J. Endocrinol. 174:517-524(2002) [PubMed] [Europe PMC] [Abstract]
  5. "A proteomic analysis of human bile."Mol. Cell. Proteomics 3:715-728(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."J. Proteome Res. 5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Proteomic analyses of the two mucus layers of the colon barrier reveal that their main component, the Muc2 mucin, is strongly bound to the Fcgbp protein."J. Proteome Res. 8:3549-3557(2009) [PubMed] [Europe PMC] [Abstract]
  9. "A strategy for precise and large scale identification of core fucosylated glycoproteins."Mol. Cell. Proteomics 8:913-923(2009) [PubMed] [Europe PMC] [Abstract]