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Solute Carrier Family 6, Member 15 (SLC6A15)

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NTT73; V7-3; SBAT1; B0AT2; Sodium-coupled branched-chain amino-acid transporter 1; Sodium-and chloride-dependent neurotransmitter transporter NTT73

Solute Carrier Family 6, Member 15 (SLC6A15)
CCC P378
HGNC 13621
MGI 2143484
PubMed 21521612
RGD 628664
UniProt Q9H2J7
Wiki SLC6A15
SLC6A15 shows structural characteristics of an Na(+) and Cl(-)-dependent neurotransmitter transporter, including 12 transmembrane (TM) domains, intracellular N and C termini, and large extracellular loops containing multiple N-glycosylation sites. Human SBAT1 mediated Na(+)-coupled transport of hydrophobic, zwitterioninc alpha-amino and imino acids when expressed in Xenopus oocytes. SBAT1 exhibited a strong preference for branched-chain amino acids and methionine, and it excluded aromatic or charged amino acids, beta-amino acids, glycine, and GABA. SBAT1-mediated transport was temperature dependent and inhibited at acidic pH. Protein kinase C activation reduced the plasma membrane population of SBAT1 protein.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Solute Carrier Family 6, Member 15 (SLC6A15) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Solute Carrier Family 6, Member 15 (SLC6A15) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Solute Carrier Family 6, Member 15 (SLC6A15) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Solute Carrier Family 6, Member 15 (SLC6A15) CLIA Kit Customized Service Offer
n/a ELISA Kit for Solute Carrier Family 6, Member 15 (SLC6A15) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Solute Carrier Family 6, Member 15 (SLC6A15) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Solute Carrier Family 6, Member 15 (SLC6A15) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Solute Carrier Family 6, Member 15 (SLC6A15) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Solute Carrier Family 6, Member 15 (SLC6A15) CLIA Kit Customized Service Offer
n/a ELISA Kit for Solute Carrier Family 6, Member 15 (SLC6A15) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Solute Carrier Family 6, Member 15 (SLC6A15) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Solute Carrier Family 6, Member 15 (SLC6A15) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Solute Carrier Family 6, Member 15 (SLC6A15) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Solute Carrier Family 6, Member 15 (SLC6A15) CLIA Kit Customized Service Offer
n/a ELISA Kit for Solute Carrier Family 6, Member 15 (SLC6A15) ELISA Kit Customized Service Offer
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  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Characterization of a branched-chain amino-acid transporter SBAT1 (SLC6A15) that is expressed in human brain."Biochem. Biophys. Res. Commun. 337:892-900(2005) [PubMed] [Europe PMC] [Abstract]
  6. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  10. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]