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Wingless Type MMTV Integration Site Family, Member 10A (WNT10A)

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Wingless Type MMTV Integration Site Family, Member 10A (WNT10A)
CCC P358
HGNC 13829
MGI 108071
PubMed 23603361
RGD 1307015
UniProt Q9GZT5
Wiki WNT10A
WNT10A is a member of the WNT gene family. It is strongly expressed in the cell lines of promyelocytic leukemia and Burkitt's lymphoma. In addition, it and another family member, the WNT6 gene, are strongly coexpressed in colorectal cancer cell lines. The gene overexpression may play key roles in carcinogenesis through activation of the WNT-beta-catenin-TCF signaling pathway. This gene and the WNT6 gene are clustered in the chromosome 2q35 region.
WNT10A encodes a deduced 417-amino acid peptide containing residues conserved among WNTs and 2 N-linked glycosylation sites. WNT10A shares 59.2% amino acid sequence identity with human WNT10B.like WNT1 and WNT10B, WNT10A and WNT6 may play key roles in human carcinogenesis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP358Hu01 Recombinant Wingless Type MMTV Integration Site Family, Member 10A (WNT10A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAP358Hu01 Polyclonal Antibody to Wingless Type MMTV Integration Site Family, Member 10A (WNT10A) WB; IHC; ICC; IP.
LAP358Hu81 FITC-Linked Polyclonal Antibody to Wingless Type MMTV Integration Site Family, Member 10A (WNT10A) WB; IHC; ICC; IF.
MAP358Hu21 Monoclonal Antibody to Wingless Type MMTV Integration Site Family, Member 10A (WNT10A) WB; IHC; ICC; IP.
Assay Kits SEP358Hu ELISA Kit for Wingless Type MMTV Integration Site Family, Member 10A (WNT10A) Enzyme-linked immunosorbent assay for Antigen Detection.
SCP358Hu CLIA Kit for Wingless Type MMTV Integration Site Family, Member 10A (WNT10A) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP358Mu01 Recombinant Wingless Type MMTV Integration Site Family, Member 10A (WNT10A) Positive Control; Immunogen; SDS-PAGE; WB.
APP358Mu01 Active Wingless Type MMTV Integration Site Family, Member 10A (WNT10A) Cell culture; Activity Assays.
Antibodies PAP358Mu01 Polyclonal Antibody to Wingless Type MMTV Integration Site Family, Member 10A (WNT10A) WB; IHC; ICC; IP.
LAP358Mu81 FITC-Linked Polyclonal Antibody to Wingless Type MMTV Integration Site Family, Member 10A (WNT10A) WB; IHC; ICC; IF.
LAP358Mu71 Biotin-Linked Polyclonal Antibody to Wingless Type MMTV Integration Site Family, Member 10A (WNT10A) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Wingless Type MMTV Integration Site Family, Member 10A (WNT10A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Wingless Type MMTV Integration Site Family, Member 10A (WNT10A) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Wingless Type MMTV Integration Site Family, Member 10A (WNT10A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Wingless Type MMTV Integration Site Family, Member 10A (WNT10A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Wingless Type MMTV Integration Site Family, Member 10A (WNT10A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Wingless Type MMTV Integration Site Family, Member 10A (WNT10A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Wingless Type MMTV Integration Site Family, Member 10A (WNT10A) ELISA Kit Customized Service Offer
  1. "WNT10A and WNT6, clustered in human chromosome 2q35 region with head-to-tail manner, are strongly co-expressed in SW480 cells."Biochem. Biophys. Res. Commun. 283:798-805(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Mutation in WNT10A is associated with an autosomal recessive ectodermal dysplasia: the odonto-onycho-dermal dysplasia."Am. J. Hum. Genet. 81:821-828(2007) [PubMed] [Europe PMC] [Abstract]
  6. "WNT10A mutations are a frequent cause of a broad spectrum of ectodermal dysplasias with sex-biased manifestation pattern in heterozygotes."Am. J. Hum. Genet. 85:97-105(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Only four genes (EDA1, EDAR, EDARADD, and WNT10A) account for 90% of hypohidrotic/anhidrotic ectodermal dysplasia cases." Hum. Mutat. 32:70-72(2011) [PubMed] [Europe PMC] [Abstract]
  8. "WNT10A and isolated hypodontia."Am. J. Med. Genet. A 155:1119-1122(2011) [PubMed] [Europe PMC] [Abstract]
  9. "Mutations in WNT10A are present in more than half of isolated hypodontia cases."J. Med. Genet. 49:327-331(2012) [PubMed] [Europe PMC] [Abstract]