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Zinc Finger With KRAB And SCAN Domains Protein 3 (ZKSCAN3)

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ZNF306; ZNF309; Zfp47; ZF47; Zinc finger and SCAN domain-containing protein 13; Zinc finger protein 47 homolog

Zinc Finger With KRAB And SCAN Domains Protein 3 (ZKSCAN3)
CCC P355
HGNC 13853
MGI 1919989
PubMed 23434374
RGD 1305753
UniProt Q9BRR0
The deduced 538-amino acid protein belongs to the Kruppel-like subfamily of C2H2 zinc finger proteins and shares significant similarity with KLF4 . ZKSCAN3 bound the consensus DNA sequence (G/T)(A/G)(A/G/T)GGGG. Expression profiling showed that 204 genes were induced 2- to 29-fold and 76 genes were reduced 2- to 5-fold by ZKSCAN3 in transfected human colon cancer cells compared with parental cells. Of the genes upregulated by ZKSCAN3, the majority encoded proteins involved in growth, cell migration, angiogenesis, and proteolysis. Expression of ZKSCAN3 was higher in invasive tumors compared with noninvasive tumors. Southern blot analysis revealed that overexpression in some tumors was partly due to gene amplification.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger With KRAB And SCAN Domains Protein 3 (ZKSCAN3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger With KRAB And SCAN Domains Protein 3 (ZKSCAN3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger With KRAB And SCAN Domains Protein 3 (ZKSCAN3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger With KRAB And SCAN Domains Protein 3 (ZKSCAN3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger With KRAB And SCAN Domains Protein 3 (ZKSCAN3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger With KRAB And SCAN Domains Protein 3 (ZKSCAN3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger With KRAB And SCAN Domains Protein 3 (ZKSCAN3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger With KRAB And SCAN Domains Protein 3 (ZKSCAN3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger With KRAB And SCAN Domains Protein 3 (ZKSCAN3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger With KRAB And SCAN Domains Protein 3 (ZKSCAN3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger With KRAB And SCAN Domains Protein 3 (ZKSCAN3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger With KRAB And SCAN Domains Protein 3 (ZKSCAN3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger With KRAB And SCAN Domains Protein 3 (ZKSCAN3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger With KRAB And SCAN Domains Protein 3 (ZKSCAN3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger With KRAB And SCAN Domains Protein 3 (ZKSCAN3) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Computer sequence analysis of human highly conserved zinc finger modules."DNA Seq. 9:163-169(1998) [PubMed] [Europe PMC] [Abstract]
  5. "The previously undescribed ZKSCAN3 (ZNF306) is a novel 'driver' of colorectal cancer progression."Cancer Res. 68:4321-4330(2008) [PubMed] [Europe PMC] [Abstract]
  6. "Unbiased screening for transcriptional targets of ZKSCAN3 identifies integrin beta 4 and vascular endothelial growth factor as downstream targets."J. Biol. Chem. 283:35295-35304(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Evidence of a role for the novel zinc-finger transcription factor ZKSCAN3 in modulating Cyclin D2 expression in multiple myeloma."Oncogene 30:1329-1340(2011) [PubMed] [Europe PMC] [Abstract]
  8. "The zinc finger transcription factor ZKSCAN3 promotes prostate cancer cell migration."Int. J. Biochem. Cell Biol. 44:1166-1173(2012) [PubMed] [Europe PMC] [Abstract]
  9. "ZKSCAN3 is a master transcriptional repressor of autophagy."Mol. Cell 50:16-28(2013) [PubMed] [Europe PMC] [Abstract]