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Itchy E3 Ubiquitin Protein Ligase Homolog (ITCH)

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AIP4; NAPP1; Atrophin-1-interacting protein 4; NFE2-associated polypeptide 1

Itchy E3 Ubiquitin Protein Ligase Homolog (ITCH)
CCC P350
HGNC 13890
MGI 1202301
RGD 1359556
UniProt Q96J02
ITCH shares 96% homology with the mouse Itch protein, which has been implicated in the regulation and differentiation of erythroid and lymphoid cells.The protein encoded by this gene interacts with atrophin-1. This encoded protein is a closely related member of the NEDD4-like protein family. This family of proteins are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. This encoded protein contains four tandem WW domains and a HECT domain. It can act as a transcriptional corepressor of p45/NFE2 and may participate in the regulation of immune responses by modifying Notch-mediated signaling. It is highly similar to the mouse Itch protein, which has been implicated in the regulation and differentiation of erythroid and lymphoid cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Itchy E3 Ubiquitin Protein Ligase Homolog (ITCH) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Itchy E3 Ubiquitin Protein Ligase Homolog (ITCH) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Itchy E3 Ubiquitin Protein Ligase Homolog (ITCH) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Itchy E3 Ubiquitin Protein Ligase Homolog (ITCH) CLIA Kit Customized Service Offer
n/a ELISA Kit for Itchy E3 Ubiquitin Protein Ligase Homolog (ITCH) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Itchy E3 Ubiquitin Protein Ligase Homolog (ITCH) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Itchy E3 Ubiquitin Protein Ligase Homolog (ITCH) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Itchy E3 Ubiquitin Protein Ligase Homolog (ITCH) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Itchy E3 Ubiquitin Protein Ligase Homolog (ITCH) CLIA Kit Customized Service Offer
n/a ELISA Kit for Itchy E3 Ubiquitin Protein Ligase Homolog (ITCH) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Itchy E3 Ubiquitin Protein Ligase Homolog (ITCH) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Itchy E3 Ubiquitin Protein Ligase Homolog (ITCH) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Itchy E3 Ubiquitin Protein Ligase Homolog (ITCH) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Itchy E3 Ubiquitin Protein Ligase Homolog (ITCH) CLIA Kit Customized Service Offer
n/a ELISA Kit for Itchy E3 Ubiquitin Protein Ligase Homolog (ITCH) ELISA Kit Customized Service Offer
  1. "Human ITCH is a co-regulator of the hematopoietic transcription factor NF-E2."Genomics 73:238-241(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins."Mol. Cell. Neurosci. 11:149-160(1998) [PubMed] [Europe PMC] [Abstract]
  6. "Latent membrane protein 2A of Epstein-Barr virus binds WW domain E3 protein-ubiquitin ligases that ubiquitinate B-cell tyrosine kinases."Mol. Cell. Biol. 20:8526-8535(2000) [PubMed] [Europe PMC] [Abstract]
  7. "Interaction between two ubiquitin-protein isopeptide ligases of different classes, CBLC and AIP4/ITCH."J. Biol. Chem. 277:45267-45275(2002) [PubMed] [Europe PMC] [Abstract]
  8. "The RING-H2 protein RNF11 is differentially expressed in breast tumours and interacts with HECT-type E3 ligases."Biochim. Biophys. Acta 1639:104-112(2003) [PubMed] [Europe PMC] [Abstract]
  9. "The E3 ubiquitin ligase AIP4 mediates ubiquitination and sorting of the G protein-coupled receptor CXCR4."Dev. Cell 5:709-722(2003) [PubMed] [Europe PMC] [Abstract]
  10. "CISK attenuates degradation of the chemokine receptor CXCR4 via the ubiquitin ligase AIP4."EMBO J. 25:3738-3749(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Itch/AIP4 mediates Deltex degradation through the formation of K29-linked polyubiquitin chains."EMBO Rep. 7:1147-1153(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Negative regulation of the E3 ubiquitin ligase itch via Fyn-mediated tyrosine phosphorylation."Mol. Cell 21:135-141(2006) [PubMed] [Europe PMC] [Abstract]
  13. "Itch regulates p45/NF-E2 in vivo by Lys63-linked ubiquitination."Biochem. Biophys. Res. Commun. 375:326-330(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Itch self-polyubiquitylation occurs through lysine-63 linkages."Biochem. Pharmacol. 76:1515-1521(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Nedd4 family-interacting protein 1 (Ndfip1) is required for the exosomal secretion of Nedd4 family proteins."J. Biol. Chem. 283:32621-32627(2008) [PubMed] [Europe PMC] [Abstract]
  16. "AIP4/Itch regulates Notch receptor degradation in the absence of ligand."PLoS ONE 3:E2735-E2735(2008) [PubMed] [Europe PMC] [Abstract]
  17. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Endogenous spartin (SPG20) is recruited to endosomes and lipid droplets and interacts with the ubiquitin E3 ligases AIP4 and AIP5."Biochem. J. 423:31-39(2009) [PubMed] [Europe PMC] [Abstract]
  19. "ITCH K63-ubiquitinates the NOD2 binding protein, RIP2, to influence inflammatory signaling pathways."Curr. Biol. 19:1255-1263(2009) [PubMed] [Europe PMC] [Abstract]
  20. "The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-kappaB signalling."EMBO J. 28:513-522(2009) [PubMed] [Europe PMC] [Abstract]
  21. "The E3 ubiquitin ligase atrophin interacting protein 4 binds directly to the chemokine receptor CXCR4 via a novel WW domain-mediated interaction."Mol. Biol. Cell 20:1324-1339(2009) [PubMed] [Europe PMC] [Abstract]
  22. "PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4."Nat. Immunol. 10:1300-1308(2009) [PubMed] [Europe PMC] [Abstract]
  23. "Human ITCH E3 ubiquitin ligase deficiency causes syndromic multisystem autoimmune disease."Am. J. Hum. Genet. 86:447-453(2010) [PubMed] [Europe PMC] [Abstract]
  24. "The E3 ubiquitin ligase Itch regulates sorting nexin 9 through an unconventional substrate recognition domain."FEBS J. 277:2803-2814(2010) [PubMed] [Europe PMC] [Abstract]
  25. "The ubiquitin ligase Itch mediates the antiapoptotic activity of epidermal growth factor by promoting the ubiquitylation and degradation of the truncated C-terminal portion of Bid."FEBS J. 277:1319-1330(2010) [PubMed] [Europe PMC] [Abstract]
  26. "The ubiquitin ligase itch regulates apoptosis by targeting thioredoxin-interacting protein for ubiquitin-dependent degradation."J. Biol. Chem. 285:8869-8879(2010) [PubMed] [Europe PMC] [Abstract]
  27. "Interactions of ErbB4 and Kap1 connect the growth factor and DNA damage response pathways."Mol. Cancer Res. 8:1388-1398(2010) [PubMed] [Europe PMC] [Abstract]
  28. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  29. "Phosphatidylinositol 4-kinase IIalpha function at endosomes is regulated by the ubiquitin ligase Itch."EMBO Rep. 13:1087-1094(2012) [PubMed] [Europe PMC] [Abstract]
  30. "Deubiquitination of EGFR by Cezanne-1 contributes to cancer progression."Oncogene 31:4599-4608(2012) [PubMed] [Europe PMC] [Abstract]
  31. "A novel interaction between atrophin-interacting protein 4 and beta-p21-activated kinase-interactive exchange factor is mediated by an SH3 domain."J. Biol. Chem. 282:28893-28903(2007) [PubMed] [Europe PMC] [Abstract]
  32. "Solution structure of the second WW domain of ITCHY homolog E3 ubiquitin protein ligase (ITCH)."Submitted (OCT-2006) to the PDB data bank