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Atonal Homolog 7 (ATOH7)

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Math5; bHLHa13; ATH5; Helix-loop-helix protein hATH-5; Class A basic helix-loop-helix protein 13

Atonal Homolog 7 (ATOH7)
CCC P349
HGNC 13907
MGI 1355553
PubMed 22645276
RGD 1304957
UniProt Q8N100
ATOH7 is a member of the family of basic helix-loop-helix (bHLH) proteins with similarity to Drosophila 'atonal,' a proneural bHLH gene that controls photoreceptor development .
Using the mouse Atoh7/Math5 cDNA to screen a genomic library, Brown et al. (2002) isolated human ATOH7 clones. Using database sequence analysis, they identified the corresponding ATOH7 cDNA, which encodes a protein that shares high sequence homology with mouse Atoh7.Brown et al. (1998) determined that mouse Atoh7 is expressed in the developing optic cup, beginning at embryonic day 11.5, in a temporal and spatial pattern that coincides with retinal ganglion cell formation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Atonal Homolog 7 (ATOH7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Atonal Homolog 7 (ATOH7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Atonal Homolog 7 (ATOH7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Atonal Homolog 7 (ATOH7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Atonal Homolog 7 (ATOH7) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Atonal Homolog 7 (ATOH7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Atonal Homolog 7 (ATOH7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Atonal Homolog 7 (ATOH7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Atonal Homolog 7 (ATOH7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Atonal Homolog 7 (ATOH7) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Atonal Homolog 7 (ATOH7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Atonal Homolog 7 (ATOH7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Atonal Homolog 7 (ATOH7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Atonal Homolog 7 (ATOH7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Atonal Homolog 7 (ATOH7) ELISA Kit Customized Service Offer
  1. "Molecular characterization and mapping of ATOH7, a human atonal homolog with a predicted role in retinal ganglion cell development."Mamm. Genome 13:95-101(2002) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening."Mech. Dev. 119:S285-S291(2002) [PubMed] [Europe PMC] [Abstract]
  4. "Deletion of a remote enhancer near ATOH7 disrupts retinal neurogenesis, causing NCRNA disease."Nat. Neurosci. 14:578-586(2011) [PubMed] [Europe PMC] [Abstract]
  5. "Genome-wide association identifies ATOH7 as a major gene determining human optic disc size." Hum. Mol. Genet. 19:2716-2724(2010) [PubMed] [Europe PMC] [Abstract]
  6. "Next generation sequencing identifies mutations in Atonal homolog 7 (ATOH7) in families with global eye developmental defects." Hum. Mol. Genet. 21:776-783(2012) [PubMed] [Europe PMC] [Abstract]
  7. "ATOH7 mutations cause autosomal recessive persistent hyperplasia of the primary vitreous."Hum. Mol. Genet. 21:3681-3694(2012) [PubMed] [Europe PMC] [Abstract]