HLA-B Associated Transcript 5 (BAT5)

Proteins of this family have 9 conserved amino acid motifs but differ at their amino and carboxyl ends. From studies of other family members, the first block is involved in ATP binding, the fifth block may be an ATPase, the sixth block is needed for RNA helicase activity, and the ninth block is involved with ATP hydrolysis-independent RNA interactions during unwinding.

The presence of additional genes was suggested by a large cluster of CpG islands. With cosmid probes, 5 distinct transcripts were detected in RNA samples from a variety of cell lines and the corresponding cDNA clones were isolated. These 'HLA-B-associated transcripts' (BAT1-BAT5) mapped to different locations within a 160-kb region that included the TNFA and TNFB genes.