Lymphocyte Antigen 6 Complex, Locus Protein G6F (LY6G6F)

The human G6f protein is a type I transmembrane protein belonging to the immunoglobin (Ig) superfamily, which is comprised of cell-surface proteins involved in the immune system and cellular recognition .

The deduced 297-amino acid protein contains a putative leader peptide, an extracellular region, a transmembrane segment, and a cytoplasmic tail with a tyrosine phosphorylation site. The N-terminal half of the extracellular region shares homology with V-type Ig domains of other proteins and contains 2 conserved cysteine residues capable of forming a disulfide bond. SDS-PAGE under nonreducing conditions yielded a 60-kD protein, which is twice the calculated molecular mass of G6f protein, suggesting that G6f forms a disulfide-linked dimer. Immunofluorescence in COS-7 cells localized G6f to the cell surface.