Carbon Catabolite Repression 4 Like Protein (CCRN4L)

CCRN4L is highly similar to Nocturnin, a gene identified as a circadian clock regulated gene in Xenopus laevis. This protein and Nocturnin protein share similarity with the C-terminal domain of a yeast transcription factor, carbon catabolite repression 4 (CCR4). The mRNA abundance of a similar gene in mouse has been shown to exhibit circadian rhythmicity, which suggests a role for this protein in clock function or as a circadian clock effector.

The deduced protein contains 439 amino acids. Mouse and human CCRN4L share 93% amino acid similarity, and both contain a conserved motif involved in Mg(2+) and Mn(2+) binding among apurinic-apyrimidinic endonuclease family I members, as well as several phosphorylation and glycosylation sites.