≡

Enhanced At Puberty 1 (EAP1)

[Edit]

IRF2BPL; C14orf4; Interferon Regulatory Factor 2 Binding Protein Like

Enhanced At Puberty 1 (EAP1)
CCC P286
HGNC 14282
MGI 2442463
PubMed 11095982
RGD 1310994
UniProt Q9H1B7
Wiki Eap1
Eap1, increased in the medial basal hypothalamus, but not cerebral cortex, of female rhesus monkeys at early puberty and increased further at midpuberty. Female mice underwent a similar increase of Eap1 expression in hypothalamus, but not cortex, during puberty. In situ hybridization showed that Eap1 mRNA was abundant in cells of hypothalamic nuclei involved in Gnrh secretion, such as the arcuate nucleus. Immunohistochemical analysis localized Eap1 to cell nuclei. Inhibition of Eap1 by RNAi targeted to the preoptic area of female rats disrupted the estrous cycle and reduced plasma gonadotropin levels, suggesting altered Gnrh release. These abnormalities were accompanied by stunted antral follicular development and formation of ovarian cysts.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Enhanced At Puberty 1 (EAP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Enhanced At Puberty 1 (EAP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Enhanced At Puberty 1 (EAP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Enhanced At Puberty 1 (EAP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Enhanced At Puberty 1 (EAP1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Enhanced At Puberty 1 (EAP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Enhanced At Puberty 1 (EAP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Enhanced At Puberty 1 (EAP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Enhanced At Puberty 1 (EAP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Enhanced At Puberty 1 (EAP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Enhanced At Puberty 1 (EAP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Enhanced At Puberty 1 (EAP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Enhanced At Puberty 1 (EAP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Enhanced At Puberty 1 (EAP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Enhanced At Puberty 1 (EAP1) ELISA Kit Customized Service Offer
  1. "Characterization of C14orf4, a novel intronless human gene containing a polyglutamine repeat, mapped to the ARVD1 critical region."Biochem. Biophys. Res. Commun. 278:766-774(2000) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  6. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Enhanced at puberty 1 (EAP1) is a new transcriptional regulator of the female neuroendocrine reproductive axis."J. Clin. Invest. 117:2145-2154(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  16. "Solution structure of the ZF-C3HC4 domain of human KIAA1865."Submitted (NOV-2005) to the PDB data bank
  17. "In silico analysis identifies a C3HC4-RING finger domain of a putative E3 ubiquitin-protein ligase located at the C-terminus of a polyglutamine-containing protein."Braz. J. Med. Biol. Res. 40:293-299(2007) [PubMed] [Europe PMC] [Abstract]