Membrane Spanning 4 Domains Subfamily A, Member 6E (MS4A6E)

MS4A6E encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. The gene encoding this protein is localized to 11q12.3, among a cluster of family members.

The putative MS4A6E gene encodes a 147-amino acid protein that is 78% identical to MS4A6A, with high homology in the hydrophobic regions and the intracellular N-terminal domain. MS4A6E lacks a C-terminal intracellular domain. RT-PCR analysis failed to detect MS4A6E transcripts in any tissues or hemopoietic cell lines tested. EST database searching identified sequences from pooled fetal organ libraries.