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Vacuolar Protein Sorting 29 (VPS29)

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PEP11; DC7; DC15; Vacuolar protein sorting-associated protein 29

Vacuolar Protein Sorting 29 (VPS29)
CCC P278
HGNC 14340
MGI 1928344
PubMed 9105038
RGD 1308332
UniProt Q9UBQ0
Wiki VPS29
VPS29 is a component of a large multimeric complex, termed the retromer complex, which is involved in retrograde transport of proteins from endosomes to the trans-Golgi network.
The deduced 20.5-kD VPS29 protein is hydrophilic and has a predicted mixed alpha-helix and beta-sheet structure. It has 2 polyadenylation signals and a charged C terminus containing the conserved NPGS amino acid motif. Northern blot analysis detected 2 transcripts of 0.8 and 2 kb corresponding to the 2 polyadenylation signals. The longer transcript was more abundant, showing highest expression in heart, skeletal muscle, and kidney, intermediate expression in brain, colon, and liver, and lowest expression in thymus, spleen, small intestine, placenta, lung, and leukocytes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Vacuolar Protein Sorting 29 (VPS29) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Vacuolar Protein Sorting 29 (VPS29) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Vacuolar Protein Sorting 29 (VPS29) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Vacuolar Protein Sorting 29 (VPS29) CLIA Kit Customized Service Offer
n/a ELISA Kit for Vacuolar Protein Sorting 29 (VPS29) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Vacuolar Protein Sorting 29 (VPS29) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Vacuolar Protein Sorting 29 (VPS29) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Vacuolar Protein Sorting 29 (VPS29) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Vacuolar Protein Sorting 29 (VPS29) CLIA Kit Customized Service Offer
n/a ELISA Kit for Vacuolar Protein Sorting 29 (VPS29) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Vacuolar Protein Sorting 29 (VPS29) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Vacuolar Protein Sorting 29 (VPS29) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Vacuolar Protein Sorting 29 (VPS29) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Vacuolar Protein Sorting 29 (VPS29) CLIA Kit Customized Service Offer
n/a ELISA Kit for Vacuolar Protein Sorting 29 (VPS29) ELISA Kit Customized Service Offer
  1. "Human homologues of yeast vacuolar protein sorting 29 and 35."Biochem. Biophys. Res. Commun. 277:622-630(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes."Mol. Biol. Cell 11:4105-4116(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The mammalian retromer regulates transcytosis of the polymeric immunoglobulin receptor."Nat. Cell Biol. 6:763-769(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The human Vps29 retromer component is a metallo-phosphoesterase for a cation-independent mannose 6-phosphate receptor substrate peptide."Biochem. J. 398:399-409(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  8. "The cargo-selective retromer complex is a recruiting hub for protein complexes that regulate endosomal tubule dynamics."J. Cell Sci. 123:3703-3717(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion."Nat. Cell Biol. 13:914-923(2011) [PubMed] [Europe PMC] [Abstract]
  11. "VPS29 is not an active metallo-phosphatase but is a rigid scaffold required for retromer interaction with accessory proteins."PLoS ONE 6:E20420-E20420(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Endosomal recruitment of the WASH complex: active sequences and mutations impairing interaction with the retromer."Biol. Cell 105:191-207(2013) [PubMed] [Europe PMC] [Abstract]
  13. "A global analysis of SNX27-retromer assembly and cargo specificity reveals a function in glucose and metal ion transport."Nat. Cell Biol. 15:461-471(2013) [PubMed] [Europe PMC] [Abstract]
  14. "VARP is recruited on to endosomes by direct interaction with retromer, where together they function in export to the cell surface."Dev. Cell 29:591-606(2014) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  16. "Crystal structure of human vacuolar protein sorting protein 29 reveals a phosphodiesterase/nuclease-like fold and two protein-protein interaction sites."J. Biol. Chem. 280:22962-22967(2005) [PubMed] [Europe PMC] [Abstract]
  17. "Functional architecture of the retromer cargo-recognition complex."Nature 449:1063-1067(2007) [PubMed] [Europe PMC] [Abstract]