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Collybistin (CB)

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ARHGEF9; PEM-2; ARHDH9; PEM-2 homolog; Rac/Cdc42 guanine nucleotide exchange factor 9; Rho guanine nucleotide exchange factor 9

Collybistin (CB)
CCC P232
HGNC 14561
MGI 2442233
PubMed 10607391
RGD 620719
UniProt O43307
Wiki Collybistin
ARHGEF9 belongs to a family of Rho-like GTPases that act as molecular switches by cycling from the active GTP-bound state to the inactive GDP-bound state.ARHGEF9 contains an N-terminal SRC homology 3 (SH3) domain, followed by tandem DBL homology (DH) and pleckstrin homology (PH) domains and a C-terminal proline-rich sequence. Northern blot analysis detected a transcript of about 6 kb expressed almost exclusively in brain. ARHGEF9, expressed in COS-7 cells, showed an apparent molecular mass of about 70 kD.ARHGEF9 specifically activates CDC42 and not Rac or RhoA. Ectopic expression in mouse fibroblasts revealed a Cdc42 phenotype featuring filopodia formation, followed by cortical actin polymerization and cell rounding.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Collybistin (CB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Collybistin (CB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Collybistin (CB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Collybistin (CB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Collybistin (CB) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Collybistin (CB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Collybistin (CB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Collybistin (CB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Collybistin (CB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Collybistin (CB) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Collybistin (CB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Collybistin (CB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Collybistin (CB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Collybistin (CB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Collybistin (CB) ELISA Kit Customized Service Offer
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  6. "Solution structure of the SH3 domain from Rho guanine nucleotide exchange factor 9."Submitted (FEB-2009) to the PDB data bank
  7. "The GDP-GTP exchange factor collybistin: an essential determinant of neuronal gephyrin clustering."J. Neurosci. 24:5816-5826(2004) [PubMed] [Europe PMC] [Abstract]
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  10. "Lipid binding defects and perturbed synaptogenic activity of a collybistinR290H mutant that causes epilepsy and intellectual disability."J. Biol. Chem. 290:8256-8270(2015) [PubMed] [Europe PMC] [Abstract]