≡

Rho Guanine Nucleotide Exchange Factor 11 (ARHGEF11)

[Edit]

GTRAP48; PDZ-RHOGEF

Rho Guanine Nucleotide Exchange Factor 11 (ARHGEF11)
CCC P230
HGNC 14580
MGI 2441869
PubMed 22665792
RGD 619705
UniProt O15085
Wiki ARHGEF11
Gtrap48 shares 90% amino acid identity with human KIAA0380, as well as significant homology with ARHGEF1. Gtrap48 possesses a PDZ domain, an RGS sequence, tandem DH and PH domains characteristic of guanine nucleotide exchange factors for the Rho family of G proteins, and 2 proline-rich sequences. Northern blot analysis detected a 7.5-kb Gtrap48 mRNA in brain tissue. Longer exposure revealed a low level of expression in liver and kidney. Gtrap48 was expressed predominantly in rat cerebellum, with low level immunoreactivity in striatum, hippocampus, and thalamus.Gtrap48 was found to activate Rho. Expression of Gtrap48 induced reorganization of the actin cytoskeleton. When Gtrap41 and Gtrap48 were coexpressed, Gtrap41 colocalized with actin in structures that resembled actin stress fibers.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Rho Guanine Nucleotide Exchange Factor 11 (ARHGEF11) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Rho Guanine Nucleotide Exchange Factor 11 (ARHGEF11) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Rho Guanine Nucleotide Exchange Factor 11 (ARHGEF11) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Rho Guanine Nucleotide Exchange Factor 11 (ARHGEF11) CLIA Kit Customized Service Offer
n/a ELISA Kit for Rho Guanine Nucleotide Exchange Factor 11 (ARHGEF11) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Rho Guanine Nucleotide Exchange Factor 11 (ARHGEF11) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Rho Guanine Nucleotide Exchange Factor 11 (ARHGEF11) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Rho Guanine Nucleotide Exchange Factor 11 (ARHGEF11) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Rho Guanine Nucleotide Exchange Factor 11 (ARHGEF11) CLIA Kit Customized Service Offer
n/a ELISA Kit for Rho Guanine Nucleotide Exchange Factor 11 (ARHGEF11) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Rho Guanine Nucleotide Exchange Factor 11 (ARHGEF11) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Rho Guanine Nucleotide Exchange Factor 11 (ARHGEF11) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Rho Guanine Nucleotide Exchange Factor 11 (ARHGEF11) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Rho Guanine Nucleotide Exchange Factor 11 (ARHGEF11) CLIA Kit Customized Service Offer
n/a ELISA Kit for Rho Guanine Nucleotide Exchange Factor 11 (ARHGEF11) ELISA Kit Customized Service Offer
  1. "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Rho-specific binding and guanine nucleotide exchange catalysis by KIAA0380, a dbl family member."FEBS Lett. 459:313-318(1999) [PubMed] [Europe PMC] [Abstract]
  5. "A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho."J. Biol. Chem. 274:5868-5879(1999) [PubMed] [Europe PMC] [Abstract]
  6. "B plexins activate Rho through PDZ-RhoGEF."FEBS Lett. 529:168-172(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF."J. Biol. Chem. 277:43115-43120(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Functions of a rho-specific guanine nucleotide exchange factor in neurite retraction. Possible role of a proline-rich motif of KIAA0380 in localization."J. Biol. Chem. 275:29570-29578(2000) [PubMed] [Europe PMC] [Abstract]
  9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  12. "HGAL, a germinal center specific protein, decreases lymphoma cell motility by modulation of the RhoA signaling pathway."Blood 116:5217-5227(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  14. "PDZ-RhoGEF ubiquitination by Cullin3-KLHL20 controls neurotrophin-induced neurite outgrowth."J. Cell Biol. 193:985-994(2011) [PubMed] [Europe PMC] [Abstract]
  15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  17. "Structure of the RGS-like domain from PDZ-RhoGEF: linking heterotrimeric g protein-coupled signaling to Rho GTPases."Structure 9:559-569(2001) [PubMed] [Europe PMC] [Abstract]
  18. "Solution structure of the PDZ domain of human Rho guanine nucleotide exchange factor 11."Submitted (OCT-2006) to the PDB data bank