Inner Mitochondrial Membrane Peptidase 2 Like Protein (IMMP2L)

The mitochondrial inner membrane peptidase (IMP) complex generates mature, active proteins in the mitochondrial intermembrane space by proteolytically removing the mitochondrial targeting presequence of nuclear-encoded proteins. IMP1 (IMMP1L) and IMP2 are the catalytic subunits of the IMP complex .

The deduced 157-amino acid human IMP2 protein contains conserved catalytic serine and lysine residues and a characteristic asn-X5-ser motif. Mouse Imp2 localized to mitochondria in transfected yeast cells.The 175-amino acid human IMMP2L protein is 41% identical to the yeast protein and 90% identical to the mouse protein. RT-PCR analysis detected IMMP2L expression in all tissues tested except adult liver and lung.