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Pre-mRNA Processing Factor 31 (PRPF31)

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PRP31; RP11; SNRNP61; U4/U6 small nuclear ribonucleoprotein Prp31; Serologically defined breast cancer antigen NY-BR-99; U4/U6 snRNP 61 kDa protein

Pre-mRNA Processing Factor 31 (PRPF31)
CCC P200
HGNC 15446
MGI 1916238
PubMed 17003455
RGD 1305832
UniProt Q8WWY3
Wiki PRPF31
PRPF31is recruited to introns following the attachment of U4 and U6 RNAs and the 15.5K protein. The addition of PRPF31 is crucial for the transition of the spliceosomal complex to the activated state. PRPF31 encodes a putative 499-amino acid protein that is 20% and 38% identical to its S. cerevisiae and S. pombe homologs, respectively. The level of sequence identity to the yeast genes indicates that PRPF31 is likely to be involved in pre-mRNA splicing. PRPF31 and its homologs all contain a region homologous to Nop, a putative snoRNA-binding domain. In yeast Prp31, the Nop domain is thought to mediate protein-RNA interactions required for spliceosome assembly. PRPF31 also has putative nuclear localization signals in its medial region, providing further evidence for a nuclear role.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pre-mRNA Processing Factor 31 (PRPF31) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pre-mRNA Processing Factor 31 (PRPF31) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pre-mRNA Processing Factor 31 (PRPF31) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pre-mRNA Processing Factor 31 (PRPF31) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pre-mRNA Processing Factor 31 (PRPF31) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pre-mRNA Processing Factor 31 (PRPF31) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pre-mRNA Processing Factor 31 (PRPF31) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pre-mRNA Processing Factor 31 (PRPF31) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pre-mRNA Processing Factor 31 (PRPF31) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pre-mRNA Processing Factor 31 (PRPF31) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pre-mRNA Processing Factor 31 (PRPF31) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pre-mRNA Processing Factor 31 (PRPF31) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pre-mRNA Processing Factor 31 (PRPF31) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pre-mRNA Processing Factor 31 (PRPF31) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pre-mRNA Processing Factor 31 (PRPF31) ELISA Kit Customized Service Offer
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  6. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF."Cell 121:873-885(2005) [PubMed] [Europe PMC] [Abstract]
  9. "The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP."RNA 12:1418-1430(2006) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "CTNNBL1 is a novel nuclear localization sequence-binding protein that recognizes RNA-splicing factors CDC5L and Prp31."J. Biol. Chem. 286:17091-17102(2011) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  16. "Binding of the human Prp31 Nop domain to a composite RNA-protein platform in U4 snRNP."Science 316:115-120(2007) [PubMed] [Europe PMC] [Abstract]
  17. "Evidence for a major retinitis pigmentosa locus on 19q13.4 (RP11) and association with a unique bimodal expressivity phenotype."Am. J. Hum. Genet. 59:864-871(1996) [PubMed] [Europe PMC] [Abstract]
  18. "A human homolog of yeast pre-mRNA splicing gene, PRP31, underlies autosomal dominant retinitis pigmentosa on chromosome 19q13.4 (RP11)."Mol. Cell 8:375-381(2001) [PubMed] [Europe PMC] [Abstract]
  19. "Disease mechanism for retinitis pigmentosa (RP11) caused by mutations in the splicing factor gene PRPF31."Hum. Mol. Genet. 11:3209-3219(2002) [PubMed] [Europe PMC] [Abstract]
  20. "Novel deletion in the pre-mRNA splicing gene PRPF31 causes autosomal dominant retinitis pigmentosa in a large Chinese family."Am. J. Med. Genet. A 121:235-239(2003) [PubMed] [Europe PMC] [Abstract]