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Diaphanous Protein Interacting Protein (DIP1)

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NCKIPSD; AF3P21; SPIN90; ORF1; WISH; WASLBP; NCK Interacting Protein With SH3 Domain; Dia Interacting Protein; Wiskott-Aldrich syndrome protein-interacting protein

Diaphanous Protein Interacting Protein (DIP1)
CCC P194
HGNC 15486
MGI 1931834
PubMed 11157975
RGD 1311323
UniProt Q9NZQ3
DIP1 is localized exclusively in the cell nucleus. It plays a role in signal transduction, and may function in the maintenance of sarcomeres and in the assembly of myofibrils into sarcomeres. It also plays an important role in stress fiber formation. The gene is involved in therapy-related leukemia by a chromosomal translocation t(3;11)(p21;q23) that involves this gene and the myeloid/lymphoid leukemia gene. Alternative splicing occurs in this locus and two transcript variants encoding distinct isoforms have been identified.
AF3p21 encodes a nuclear protein consisting of 722 amino acids with an SH3 domain, a proline-rich domain, and a bipartite nuclear localization signal. The protein's SH3 domain has high homology with that of FYN .

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Diaphanous Protein Interacting Protein (DIP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Diaphanous Protein Interacting Protein (DIP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Diaphanous Protein Interacting Protein (DIP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Diaphanous Protein Interacting Protein (DIP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Diaphanous Protein Interacting Protein (DIP1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Diaphanous Protein Interacting Protein (DIP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Diaphanous Protein Interacting Protein (DIP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Diaphanous Protein Interacting Protein (DIP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Diaphanous Protein Interacting Protein (DIP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Diaphanous Protein Interacting Protein (DIP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Diaphanous Protein Interacting Protein (DIP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Diaphanous Protein Interacting Protein (DIP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Diaphanous Protein Interacting Protein (DIP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Diaphanous Protein Interacting Protein (DIP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Diaphanous Protein Interacting Protein (DIP1) ELISA Kit Customized Service Offer
  1. "Novel SH3 protein encoded by the AF3p21 gene is fused to the mixed lineage leukemia protein in a therapy-related leukemia with t(3;11)(p21;q23)."Blood 95:1066-1068(2000) [PubMed] [Europe PMC] [Abstract]
  2. "The VacA toxin of Helicobacter pylori identifies a new intermediate filament-interacting protein."EMBO J. 19:48-56(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Genomic organization, tissue expression and cellular localization of AF3p21, a fusion partner of MLL in therapy-related leukemia."Genes Chromosomes Cancer 30:364-374(2001) [PubMed] [Europe PMC] [Abstract]
  4. "SPIN90 (SH3 protein interacting with Nck, 90 kDa), an adapter protein that is developmentally regulated during cardiac myocyte differentiation."J. Biol. Chem. 276:12871-12878(2001) [PubMed] [Europe PMC] [Abstract]
  5. "mDia-interacting protein acts downstream of rho-mDia and modifies src activation and stress fiber formation."J. Biol. Chem. 276:39290-39294(2001) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of FHOD1-binding proteins and mechanisms of FHOD1-regulated actin dynamics."J. Cell. Biochem. 92:29-41(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening."BMC Immunol. 10:53-53(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "Identification of IGPR-1 as a novel adhesion molecule involved in angiogenesis."Mol. Biol. Cell 23:1646-1656(2012) [PubMed] [Europe PMC] [Abstract]
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]