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DEAH Box Polypeptide 29 (DHX29)

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DDX29; Asp-Glu-Ala-Asp/His Box Polypeptide 29; Nucleic acid helicase DDXx

DEAH Box Polypeptide 29 (DHX29)
CCC P172
HGNC 15815
MGI 2145374
PubMed 19109895
UniProt Q7Z478
The 43S preinitiation complex containing 40S ribosomal subunits, EIF3, EIF2, EIF1, EIF1A (EIF1AX), and initiator tRNA binds to and scans 5-prime UTRs of mRNAs to identify the initiation codon, where it stops to form the 48S initiation complex. Scanning of unstructured 5-prime UTRs does not require ATP or factors associated with ATP hydrolysis and RNA unwinding, whereas scanning of 5-prime UTRs with even weak secondary structure requires ATP and EIF4A, EIF4G, and EIF4B. Dhx29 bound 40S ribosomal subunits and hydrolyzed ATP, GTP, UTP, and CTP. NTPase activity of Dhx29 was strongly stimulated by 43S complexes, and Dhx29 stimulated 48S complex formation most strongly when it was present in substoichiometric amounts relative to 43S complexes. Rabbit Dhx29 did not show processive helicase activity.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DEAH Box Polypeptide 29 (DHX29) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DEAH Box Polypeptide 29 (DHX29) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DEAH Box Polypeptide 29 (DHX29) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DEAH Box Polypeptide 29 (DHX29) CLIA Kit Customized Service Offer
n/a ELISA Kit for DEAH Box Polypeptide 29 (DHX29) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DEAH Box Polypeptide 29 (DHX29) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DEAH Box Polypeptide 29 (DHX29) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DEAH Box Polypeptide 29 (DHX29) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DEAH Box Polypeptide 29 (DHX29) CLIA Kit Customized Service Offer
n/a ELISA Kit for DEAH Box Polypeptide 29 (DHX29) ELISA Kit Customized Service Offer
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