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MRG-Binding Protein (MRGBP)

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MRG15BP; C20orf20; Eaf7; Urcc4; Up-regulated in colon cancer 4; MRG/MORF4L-binding protein

MRG-Binding Protein (MRGBP)
CCC P166
HGNC 15866
MGI 1920497
PubMed 21535316
RGD 1308612
UniProt Q9NV56
Cai et al. (2003) demonstrated that epitope-tagged rat Mrgbp associated with the TRRAP/TIP60 (HTATIP) histone acetyltransferase complex in transfected HeLa cells. Within this complex, Mrgbp bound directly to MRG15 (MORF4L1) and MRGX (MORF4L2).The International Radiation Hybrid Mapping Consortium mapped the C20ORF20 gene to chromosome 20. A null mutation of Trrap in mice results in preimplantation lethality due to a blocked proliferation of blastocysts. Trrap-deficient cells failed to sustain mitotic arrest despite chromosome missegregation and disrupted spindles, and displayed compromised cdk1 activity. Trrap is, therefore, essential for early development and required for the mitotic checkpoint and normal cell cycle progression.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MRG-Binding Protein (MRGBP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MRG-Binding Protein (MRGBP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MRG-Binding Protein (MRGBP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for MRG-Binding Protein (MRGBP) CLIA Kit Customized Service Offer
n/a ELISA Kit for MRG-Binding Protein (MRGBP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MRG-Binding Protein (MRGBP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MRG-Binding Protein (MRGBP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MRG-Binding Protein (MRGBP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for MRG-Binding Protein (MRGBP) CLIA Kit Customized Service Offer
n/a ELISA Kit for MRG-Binding Protein (MRGBP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MRG-Binding Protein (MRGBP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MRG-Binding Protein (MRGBP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MRG-Binding Protein (MRGBP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for MRG-Binding Protein (MRGBP) CLIA Kit Customized Service Offer
n/a ELISA Kit for MRG-Binding Protein (MRGBP) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex."J. Biol. Chem. 278:42733-42736(2003) [PubMed] [Europe PMC] [Abstract]
  5. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]