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Trihydrophobin 1 (TH1)

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TH1L; NELFCD; NELF-C; NELF-D; TH1-Like; Negative elongation factor C/D

Trihydrophobin 1 (TH1)
CCC P162
HGNC 15934
MGI 1926424
UniProt Q8IXH7
The TH1L gene encodes NELFC and NELFD, either of which is included as a subunit of negative elongation factor (NELF). NELF, which also includes NELFA (WHSC2), NELFB, and NELFE (RDBP), acts with DRB sensitivity-inducing factor (DSIF), a heterodimer of SPT4 (SUPT4H1) and SPT5 (SUPT5H), to cause transcriptional pausing of RNA polymerase II.
The deduced human 581-amino acid protein shares 98% sequence identity with the mouse protein. There is, however, no similar protein in C. elegans. Northern blot analysis demonstrated a single 2.4-kb transcript in all tissues tested, with highest levels in cardiac and skeletal muscle, kidney, adrenal, and thyroid. By SDS-PAGE, NELFC and NELFD had apparent molecular masses of 60 and 59 kD, respectively.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Trihydrophobin 1 (TH1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Trihydrophobin 1 (TH1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Trihydrophobin 1 (TH1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Trihydrophobin 1 (TH1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Trihydrophobin 1 (TH1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Trihydrophobin 1 (TH1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Trihydrophobin 1 (TH1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Trihydrophobin 1 (TH1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Trihydrophobin 1 (TH1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Trihydrophobin 1 (TH1) ELISA Kit Customized Service Offer
  1. "Characterization of TH1 and CTSZ, two non-imprinted genes downstream of GNAS1 in chromosome 20q13."Hum. Genet. 107:165-175(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex."Mol. Cell. Biol. 23:1863-1873(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of TH1 as an interaction partner of A-Raf kinase."Mol. Cell. Biochem. 231:69-74(2002) [PubMed] [Europe PMC] [Abstract]
  8. "NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation."Cell 97:41-51(1999) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]