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Rhomboid, Veinlet Like Protein 2 (RHBDL2)

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RRP2; Rhomboid-related protein 2

Rhomboid, Veinlet Like Protein 2 (RHBDL2)
CCC P140
HGNC 16083
MGI 3608413
PubMed 21833011
RGD 1308295
UniProt Q9NX52
RHBDL2 is a member of the rhomboid family of integral membrane proteins. This family contains proteins that are related to Drosophila rhomboid protein. Members of this family are found in both prokaryotes and eukaryotes and are thought to function as intramembrane serine proteases. The encoded protein is thought to release soluble growth factors by proteolytic cleavage of certain membrane-bound substrates, including ephrin B2 and ephrin B3.
The deduced 293-amino acid protein shares 32% identity with Drosophila Rhomboid-1. RHBDL2 contains the conserved asp, his, and ser residues of the serine protease catalytic triad. RHBDL2 was unable to cleave the membrane domains of human EGF receptor ligands following transfection in human embryonic kidney cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Rhomboid, Veinlet Like Protein 2 (RHBDL2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Rhomboid, Veinlet Like Protein 2 (RHBDL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Rhomboid, Veinlet Like Protein 2 (RHBDL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Rhomboid, Veinlet Like Protein 2 (RHBDL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Rhomboid, Veinlet Like Protein 2 (RHBDL2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Rhomboid, Veinlet Like Protein 2 (RHBDL2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Rhomboid, Veinlet Like Protein 2 (RHBDL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Rhomboid, Veinlet Like Protein 2 (RHBDL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Rhomboid, Veinlet Like Protein 2 (RHBDL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Rhomboid, Veinlet Like Protein 2 (RHBDL2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Rhomboid, Veinlet Like Protein 2 (RHBDL2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Rhomboid, Veinlet Like Protein 2 (RHBDL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Rhomboid, Veinlet Like Protein 2 (RHBDL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Rhomboid, Veinlet Like Protein 2 (RHBDL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Rhomboid, Veinlet Like Protein 2 (RHBDL2) ELISA Kit Customized Service Offer
  1. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Drosophila Rhomboid-1 defines a family of putative intramembrane serine proteases."Cell 107:173-182(2001) [PubMed] [Europe PMC] [Abstract]
  5. "Intramembrane cleavage of ephrinB3 by the human rhomboid family protease, RHBDL2."Biochem. Biophys. Res. Commun. 317:244-252(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The processing of human rhomboid intramembrane serine protease RHBDL2 is required for its proteolytic activity."J. Mol. Biol. 394:815-825(2009) [PubMed] [Europe PMC] [Abstract]