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SYS1 Golgi Localized Integral Membrane Protein Homolog (SYS1)

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C20orf169

SYS1 Golgi Localized Integral Membrane Protein Homolog (SYS1)
CCC P131
HGNC 16162
PubMed 12941277
UniProt Q8N2H4
SYS1 forms a complex with ADP-ribosylation factor-related protein ARFRP1 and targets ARFRP1 to the Golgi apparatus. SYS1 as a deduced 194-amino acid protein containing 4 predicted transmembrane domains.
SYS1 is localized to the Golgi and arranged with its C terminus in the cytosol, consistent with immunofluorescence localization of S. cerevisiae Sys1 to the plasma-membrane side of the Golgi.human SYS1 plays a role in the intracellular distribution of ARFRP1, and that the ARFRP1 N-terminal helix is required for this function. Chemical crosslinking and coimmunoprecipitation studies demonstrated SYS1-ARFRP1 interaction and formation of a protein complex.SYS1 forms a complex with the N-terminal acetylated form of ARFRP1, and then targets ARFRP1 to the Golgi.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SYS1 Golgi Localized Integral Membrane Protein Homolog (SYS1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SYS1 Golgi Localized Integral Membrane Protein Homolog (SYS1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SYS1 Golgi Localized Integral Membrane Protein Homolog (SYS1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SYS1 Golgi Localized Integral Membrane Protein Homolog (SYS1) CLIA Kit Customized Service Offer
n/a ELISA Kit for SYS1 Golgi Localized Integral Membrane Protein Homolog (SYS1) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Targeting of the Arf-like GTPase Arl3p to the Golgi requires N-terminal acetylation and the membrane protein Sys1p."Nat. Cell Biol. 6:405-413(2004) [PubMed] [Europe PMC] [Abstract]