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Tripartite Motif Containing Protein 22 (TRIM22)

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STAF50; GPSTAF50; RNF94; E3 ubiquitin-protein ligase TRIM22; 50 kDa-stimulated trans-acting factor; RING finger protein 94

Tripartite Motif Containing Protein 22 (TRIM22)
CCC P109
HGNC 16379
PubMed 23408607
UniProt Q8IYM9
Wiki TRIM22
TRIM22 is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the cytoplasm and its expression is induced by interferon.
The protein down-regulates transcription from the HIV-1 LTR promoter region, suggesting that function of this protein may be to mediate interferon's antiviral effects. Sequence analysis predicted that the 442-amino acid protein is 44% and 41% identical to mouse Rpt1 and human SSA/RO52 (SSA1), respectively. It contains a ring finger, an intermediate motif, and a CHC3H2 zinc finger in its N terminus, as well as a central bipartite nuclear localization signal. TRIM22 may be involved in the transduction of IFN antiviral action.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tripartite Motif Containing Protein 22 (TRIM22) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tripartite Motif Containing Protein 22 (TRIM22) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tripartite Motif Containing Protein 22 (TRIM22) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tripartite Motif Containing Protein 22 (TRIM22) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tripartite Motif Containing Protein 22 (TRIM22) ELISA Kit Customized Service Offer
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  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The tripartite motif family identifies cell compartments."EMBO J. 20:2140-2151(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Staf50 is a novel p53 target gene conferring reduced clonogenic growth of leukemic U-937 cells."Oncogene 23:4050-4059(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Identification of TRIM22 as a RING finger E3 ubiquitin ligase."Biochem. Biophys. Res. Commun. 374:502-506(2008) [PubMed] [Europe PMC] [Abstract]
  6. "The interferon response inhibits HIV particle production by induction of TRIM22."PLoS Pathog. 4:E1000007-E1000007(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Dynamic localization of tripartite motif-containing 22 in nuclear and nucleolar bodies."Exp. Cell Res. 315:1521-1532(2009) [PubMed] [Europe PMC] [Abstract]
  8. "B30.2/SPRY domain in tripartite motif-containing 22 is essential for the formation of distinct nuclear bodies."FEBS Lett. 583:2093-2099(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Tripartite motif-containing 22 inhibits the activity of hepatitis B virus core promoter, which is dependent on nuclear-located RING domain."Hepatology 50:424-433(2009) [PubMed] [Europe PMC] [Abstract]
  10. "TRIM22 E3 ubiquitin ligase activity is required to mediate antiviral activity against encephalomyocarditis virus."J. Gen. Virol. 90:536-545(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]