≡

Zinc Finger Protein 350 (ZNF350)

[Edit]

ZBRK1; ZFQR; KRAB zinc finger protein ZFQR; Zinc finger and BRCA1-interacting protein with a KRAB domain 1; Zinc finger protein ZBRK1

Zinc Finger Protein 350 (ZNF350)
CCC P076
HGNC 16656
PubMed 23151675
UniProt Q9GZX5
Wiki ZNF350
ZBRK1 binds to a specific sequence, GGGxxxCAGxxxTTT, within GADD45 intron 3 that supports the assembly of a nuclear complex minimally containing both ZBRK1 and BRCA1. Through this recognition sequence, ZBRK1 represses transcription in a BRCA1-dependent manner. The results revealed a novel corepressor function for BRCA1 and provided a mechanistic basis for the biologic activity of BRCA1 through sequence-specific transcriptional regulation.
ZBRK1 is rapidly degraded upon treatment of an osteosarcoma cell line with the DNA-damaging agents, ultraviolet light and methyl methanesulfonate. Inhibitors of the ubiquitin-proteasome pathway blocked degradation of ZBRK1. Cells expressing this mutant were hypersensitive to DNA damage and were compromised for GADD45 derepression.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger Protein 350 (ZNF350) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger Protein 350 (ZNF350) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger Protein 350 (ZNF350) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger Protein 350 (ZNF350) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger Protein 350 (ZNF350) ELISA Kit Customized Service Offer
  1. "Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1."Mol. Cell 6:757-768(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Characterization of a novel zinc finger gene with increased expression in nondividing normal human cells."Exp. Cell Res. 263:156-162(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1."Cell. Mol. Life Sci. 70:3947-3958(2013) [PubMed] [Europe PMC] [Abstract]
  7. "Mutational analysis of the BRCA1-interacting genes ZNF350/ZBRK1 and BRIP1/BACH1 among BRCA1 and BRCA2-negative probands from breast-ovarian cancer families and among early-onset breast cancer cases and reference individuals."Hum. Mutat. 22:121-128(2003) [PubMed] [Europe PMC] [Abstract]
  8. "An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein."Oncogene 23:1801-1808(2004) [PubMed] [Europe PMC] [Abstract]