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Zinc Finger And BTB Domain Containing Protein 33 (ZBTB33)

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ZNF-kaiso; KAISO; ZNF348

Zinc Finger And BTB Domain Containing Protein 33 (ZBTB33)
CCC P071
HGNC 16682
MGI 1927290
PubMed 24040197
RGD 1566309
UniProt Q86T24
Wiki ZBTB33
ZBTB33 encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA.
The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger And BTB Domain Containing Protein 33 (ZBTB33) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger And BTB Domain Containing Protein 33 (ZBTB33) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger And BTB Domain Containing Protein 33 (ZBTB33) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger And BTB Domain Containing Protein 33 (ZBTB33) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger And BTB Domain Containing Protein 33 (ZBTB33) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger And BTB Domain Containing Protein 33 (ZBTB33) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger And BTB Domain Containing Protein 33 (ZBTB33) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger And BTB Domain Containing Protein 33 (ZBTB33) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger And BTB Domain Containing Protein 33 (ZBTB33) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger And BTB Domain Containing Protein 33 (ZBTB33) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger And BTB Domain Containing Protein 33 (ZBTB33) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger And BTB Domain Containing Protein 33 (ZBTB33) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger And BTB Domain Containing Protein 33 (ZBTB33) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger And BTB Domain Containing Protein 33 (ZBTB33) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger And BTB Domain Containing Protein 33 (ZBTB33) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor."Mol. Cell. Biol. 19:3614-3623(1999) [PubMed] [Europe PMC] [Abstract]
  6. "The p120 catenin partner Kaiso is a DNA methylation-dependent transcriptional repressor."Genes Dev. 15:1613-1618(2001) [PubMed] [Europe PMC] [Abstract]
  7. "N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso."Mol. Cell 12:723-734(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Kaiso is a genome-wide repressor of transcription that is essential for amphibian development."Development 131:6185-6194(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Laminar shear stress differentially modulates gene expression of p120 catenin, Kaiso transcription factor, and vascular endothelial cadherin in human coronary artery endothelial cells."J. Biol. Chem. 279:11417-11424(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Nuclear import of the BTB/POZ transcriptional regulator Kaiso."J. Cell Sci. 117:6143-6152(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Expression and nuclear location of the transcriptional repressor Kaiso is regulated by the tumor microenvironment."Cancer Res. 65:2224-2233(2005) [PubMed] [Europe PMC] [Abstract]
  12. "The catenin p120ctn inhibits Kaiso-mediated transcriptional repression of the beta-catenin/TCF target gene matrilysin."Exp. Cell Res. 305:253-265(2005) [PubMed] [Europe PMC] [Abstract]
  13. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Crystal structure of human zinc finger and BTB domain containing 33."Submitted (DEC-2008) to the PDB data bank