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Polymerase DNA Directed Sigma (POLs)

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PAPD7; POLK; TRF4; LAK-1; TRF4-1; Topoisomerase-Related Function Protein 4-1; DNA Polymerase Kappa; PAP Associated Domain Containing 7; Terminal uridylyltransferase 5

Polymerase DNA Directed Sigma (POLs)
CCC P063
HGNC 16705
MGI 2682295
RGD 1307356
UniProt Q5XG87
One clone (TRF4-1) contained an insert encoding a potential TRF4-related open reading frame of 517 amino acids with a potential initiator methionine at position 41. The sequence included all the regions of high evolutionary conservation in the TRF4 gene family. Saccharomyces cerevisiae and human TRF4-1 are 39% identical over 310 amino acids in the central region of both proteins.
A double mutant in the redundant homologs TRF4 and TRF5 is unable to complete S phase, whereas a TRF4 single mutant completes a presumably defective S phase that results in the failure of cohesion between the replicated sister chromatids. This suggested that TRFs are a key link in the coordination between DNA replication and sister chromatid cohesion.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Polymerase DNA Directed Sigma (POLs) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Polymerase DNA Directed Sigma (POLs) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Polymerase DNA Directed Sigma (POLs) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Polymerase DNA Directed Sigma (POLs) CLIA Kit Customized Service Offer
n/a ELISA Kit for Polymerase DNA Directed Sigma (POLs) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Polymerase DNA Directed Sigma (POLs) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Polymerase DNA Directed Sigma (POLs) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Polymerase DNA Directed Sigma (POLs) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Polymerase DNA Directed Sigma (POLs) CLIA Kit Customized Service Offer
n/a ELISA Kit for Polymerase DNA Directed Sigma (POLs) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Polymerase DNA Directed Sigma (POLs) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Polymerase DNA Directed Sigma (POLs) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Polymerase DNA Directed Sigma (POLs) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Polymerase DNA Directed Sigma (POLs) CLIA Kit Customized Service Offer
n/a ELISA Kit for Polymerase DNA Directed Sigma (POLs) ELISA Kit Customized Service Offer
  1. "The topoisomerase-related function gene TRF4 affects cellular sensitivity to the antitumor agent camptothecin."J. Biol. Chem. 274:7302-7308(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning and characterization of a novel isoform of the non-canonical poly(A) polymerase PAPD7."Biochem. Biophys. Res. Commun. 432:135-140(2013) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Pol kappa: a DNA polymerase required for sister chromatid cohesion."Science 289:774-779(2000) [PubMed] [Europe PMC] [Abstract]
  6. "Evidence that replication fork components catalyze establishment of cohesion between sister chromatids."Proc. Natl. Acad. Sci. U.S.A. 98:8270-8275(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'."Genes Dev. 22:50-65(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Comparison of the yeast and human nuclear exosome complexes."Biochem. Soc. Trans. 40:850-855(2012) [PubMed] [Europe PMC] [Abstract]