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Serine/Arginine Rich Splicing Factor 10 (SRSF10)

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FUSIP2; FUSIP1; SFRS13A; TASR1; TASR2; SRp38; SRrp40; SFRS13; NSSR; FUS-Interacting Protein; Neural-Salient SR Protein; 40 kDa SR-repressor protein

Serine/Arginine Rich Splicing Factor 10 (SRSF10)
CCC P061
HGNC 16713
MGI 1333805
PubMed 21984158
UniProt O75494
SRSF10 is a member of the serine-arginine (SR) family of proteins, which is involved in constitutive and regulated RNA splicing. Members of this family are characterized by N-terminal RNP1 and RNP2 motifs, which are required for binding to RNA, and multiple C-terminal SR/RS repeats, which are important in mediating association with other cellular proteins. This protein can influence splice site selection of adenovirus E1A pre-mRNA.
It interacts with the oncoprotein TLS, and abrogates the influence of TLS on E1A pre-mRNA splicing. This gene has multiple pseudogenes. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. In addition, transcript variants utilizing alternative polyA sites exist.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Serine/Arginine Rich Splicing Factor 10 (SRSF10) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Serine/Arginine Rich Splicing Factor 10 (SRSF10) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Serine/Arginine Rich Splicing Factor 10 (SRSF10) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Serine/Arginine Rich Splicing Factor 10 (SRSF10) CLIA Kit Customized Service Offer
n/a ELISA Kit for Serine/Arginine Rich Splicing Factor 10 (SRSF10) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Serine/Arginine Rich Splicing Factor 10 (SRSF10) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Serine/Arginine Rich Splicing Factor 10 (SRSF10) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Serine/Arginine Rich Splicing Factor 10 (SRSF10) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Serine/Arginine Rich Splicing Factor 10 (SRSF10) CLIA Kit Customized Service Offer
n/a ELISA Kit for Serine/Arginine Rich Splicing Factor 10 (SRSF10) ELISA Kit Customized Service Offer
  1. "Oncoprotein TLS interacts with serine-arginine proteins involved in RNA splicing."J. Biol. Chem. 273:27761-27764(1998) [PubMed] [Europe PMC] [Abstract]
  2. "TLS-ERG leukemia fusion protein inhibits RNA splicing mediated by serine-arginine proteins."Mol. Cell. Biol. 20:3345-3354(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Serine-arginine (SR) protein-like factors that antagonize authentic SR proteins and regulate alternative splicing."J. Biol. Chem. 276:48908-48914(2001) [PubMed] [Europe PMC] [Abstract]
  4. "The SR protein SRp38 represses splicing in M Phase cells."Cell 111:407-417(2002) [PubMed] [Europe PMC] [Abstract]
  5. "Characterization and expression of the human gene encoding two translocation liposarcoma protein-associated serine-arginine (TASR) proteins."Gene 284:141-147(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Dephosphorylated SRp38 acts as a splicing repressor in response to heat shock."Nature 427:553-558(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]